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Visar resultat 11 - 15 av 3230 avhandlingar som matchar ovanstående sökkriterier.

  1. 11. Refined in vitro Models for Prediction of Intestinal Drug Transport : Role of pH and Extracellular Additives in the Caco-2 Cell Model

    Författare :Sibylle Neuhoff; Per Artursson; Anna-Lena Ungell; Patrick Augustijns; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; Caco-2 cells; membrane permeability; drug permeation; drug efflux ratios; drug uptake ratios; Cremophor EL; bovine serum albumin; pH-dependent permeability; drug transport; FARMACI; PHARMACY; FARMACI;

    Sammanfattning : Drug transport across the intestinal epithelium is roughly predicted from permeability values obtained from Caco-2 cell monolayers. This thesis examines the important role of pH and extracellular additives for increasing the reliability and predictivity of the in vitro screening system, Caco-2. LÄS MER

  3. 12. Drug Eluting Hydrogels : Design, Synthesis and Evaluation

    Författare :Lage Ahrenstedt; Deon Bezuidenhout; Michael Malkoch; University of Cape Town; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Drug delivery; PEGylation; Rapamycin; Dexamethasone; Controlled release; Hydrogels; Slow release;

    Sammanfattning : Hydrogels have successfully proved themselves useful for drug delivery applications and several delivery routes have been developed over the years. The particular interest in this work was to design, synthesise and evaluate in situ forming drug eluting hydrogels, which have the potential to ameliorate the healing of cardiovascular diseases. LÄS MER

  4. 13. Skapande av femininitet : Om kvinnor i missbrukarbehandling

    Författare :Leili Laanemets; Socialhögskolan; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; client; drug use; drug abuse; drugs; alcohol; drug treatment; addiction treatment; motherhood; sex; gender; femininity; women; Social problems and welfare; national insurance; Sociala problem; social välfärd; socialförsäkring;

    Sammanfattning : This thesis is about women in drug abuse treatment and their descriptions of themselves as women - their process of becoming feminine. The aim of the thesis is describing and trying to understand the meaning of the treatment in the women's femininity processes and what significance drugs, alcohol, men, the own body, motherhood, and sexuality have and have had in the process. LÄS MER

  5. 14. Socially Integrated Drug Users : Between Deviance and Normality

    Författare :Sharon Rødner Sznitman; Robin Room; Adrienne Sörbom; Geoffrey Hunt; Stockholms universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Socially integrated drug users; Sweden; Switzerland; drug normalization; mixed methods; Sociology; Sociologi; Sociology; sociologi;

    Sammanfattning : The purpose of this thesis is to improve our knowledge of substance users in the normal population. The main concern is with how the meaning of drug use is constructed. To answer this, the thesis draws on different theoretical principles and mixed methods design. The thesis is made up of four sub-studies, with interconnected foci. LÄS MER

  7. 15. Microgels as drug delivery vehicles : loading and release of amphiphilic drugs

    Författare :Yassir Al-Tikriti; Per Hansson; Magnus Bergström; Matthew Libera; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; microgel; amphiphilic drug; phase separation; micropipette; Raman microscopy; controlled release; drug delivery; SAXS; Pharmaceutical Physical Chemistry; Farmaceutisk fysikalisk kemi;

    Sammanfattning : Polyelectrolyte microgels are used as delivery vehicles for amphiphilic drugs in, e.g., treatments of liver cancer by a method called trans-arterial chemoembolization. LÄS MER