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Visar resultat 21 - 25 av 3230 avhandlingar som matchar ovanstående sökkriterier.

1. 21. In Vivo Active Drug Uptake and Efflux at the Blood-Brain Barrier : With Focus on Drug Transport Interactions

   Författare :Muhammad Waqas Sadiq; Margareta Hammarlund-Udenaes; Sven Björkman; N. Joan Abbott; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Blood-brain barrier; Active uptake transport; Microdialysis; P-glycoprotein; Drug interactions; Species differences; Pharmacokinetics; Pharmacodynamics; NONMEM; Pharmaceutical Science; Farmaceutisk vetenskap;

   Sammanfattning : The blood-brain barrier (BBB) controls the movement of substances into and out of the brain. The tight junctions between endothelial cells and energy dependent transporters in the BBB influence rate and extent of drug distribution to the brain. LÄS MER

3. 22. Towards Individualized Drug Dosage : General Methods and Case Studies

   Författare :Martin Fransson; Peter Fritzson; Lena Friberg; Linköpings universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; drug dosage; population pharmacokinetics; biochemical modelling; identifiability; parameter estimation; Bioinformatics; Bioinformatik;

   Sammanfattning : Progress in individualized drug treatment is of increasing importance, promising to avoid much human suffering and reducing medical treatment costs for society. The strategy is to maximize the therapeutic effects and minimize the negative side effects of a drug on individual or group basis. LÄS MER

4. 23. Proteomic and Functional Analysis of In Vitro Systems for Studies of Drug Disposition in the Human Small Intestine and Liver

   Författare :Magnus Ölander; Per Artursson; Pär Matsson; Edward L. LeCluyse; Volker Lauschke; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proteomics; drug disposition; ADMET; drug transport; drug metabolism; hepatotoxicity; small intestine; liver; caco-2; human hepatocytes; cryopreservation; apoptosis; liver zonation; non-parenchymal cells; Farmaceutisk vetenskap; Pharmaceutical Science;

   Sammanfattning : To reach the bloodstream, an orally administered drug must be absorbed through the small intestine and avoid extensive clearance in the liver. Estimating these parameters in vitro is therefore important in drug discovery and development. LÄS MER

5. 24. Drug discovery against leishmaniasis : Bio- and chemoinformatic guided strategies for target evaluation and hit identification

   Författare :Elisabet Vikeved; UCM Alsmark; Christian Sköld; David Horn; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Leishmaniasis; Drug discovery; Lateral gene transfer; Comparative genomics; Virtual screening; Target fishing; Marine natural products;

   Sammanfattning : Leishmaniasis is a neglected tropical disease mainly affecting poor people in developing countries. It is caused by infections of flagellated protozoa belonging to genus Leishmania. The few available drugs are associated with problems such as low effectiveness, severe side effects and resistance development. LÄS MER

7. 25. Interaction Studies of Secreted Aspartic Proteases (Saps) from Candida albicans : Application for Drug Discovery

   Författare :Dan Backman; Helena Danielson; Birgitta Tomkinson; Gunnar Henriksson; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; SPR Biosensor; Secreted aspartic proteases; Candida albicans; interaction kinetics; drug discovery; protease inhibitor; Biokemi; Biochemistry; Biokemi;

   Sammanfattning : This thesis is focused on enzymatic studies of the secreted aspartic proteases (Saps) from Candida albicans as a tool for discovery of anti-candida drugs. C. albicans causes infections in a number of different locations, which differ widely in the protein substrates available and pH. Since C. LÄS MER