Sökning: "pH-dependent permeability"
Hittade 4 avhandlingar innehållade orden pH-dependent permeability.
1. Refined in vitro Models for Prediction of Intestinal Drug Transport : Role of pH and Extracellular Additives in the Caco-2 Cell Model
Sammanfattning : Drug transport across the intestinal epithelium is roughly predicted from permeability values obtained from Caco-2 cell monolayers. This thesis examines the important role of pH and extracellular additives for increasing the reliability and predictivity of the in vitro screening system, Caco-2. LÄS MER
2. Computational and Experimental Models for the Prediction of Intestinal Drug Solubility and Absorption
Sammanfattning : New effective experimental techniques in medicinal chemistry and pharmacology have resulted in a vast increase in the number of pharmacologically interesting compounds. However, the number of new drugs undergoing clinical trial has not augmented at the same pace, which in part has been attributed to poor absorption of the compounds. LÄS MER
Sammanfattning : The stability of phospholipid lipomes interacting with micelle-forming surfactants was studied under physiological conditions (150 mM NaCl and pH=7.4 unless otherwise stated) mainly by use of cryo-TEM and fluorescence. LÄS MER
Sammanfattning : Crimean-Congo hemorrhagic fever (CCHF) is a severe acute human disease with potential lethal outcome caused by a virus, Crimean-Congo hemorrhagic fever virus (CCHFV). Not much is known regarding how CCHFV infects cells, replicates and why it cause vascular dysfunction. LÄS MER