Sökning: "Cremophor EL"
Hittade 3 avhandlingar innehållade orden Cremophor EL.
1. Refined in vitro Models for Prediction of Intestinal Drug Transport : Role of pH and Extracellular Additives in the Caco-2 Cell Model
Sammanfattning : Drug transport across the intestinal epithelium is roughly predicted from permeability values obtained from Caco-2 cell monolayers. This thesis examines the important role of pH and extracellular additives for increasing the reliability and predictivity of the in vitro screening system, Caco-2. LÄS MER
Sammanfattning : Paclitaxel (Taxol®) is now widely used against breast, ovarian and non-small-cell lung cancer. Anticancer agents generally have narrow therapeutic indices, often with myelosuppression (mainly neutropenia) as dose-limiting side effect. LÄS MER
3. Mathematical model development to investigate the pharmacokinetic variability of two anticancer drugs
Sammanfattning : Pharmacokinetic variability in a population is the variability in plasma drug concentrations among individuals. It may, for instance, be caused by differences in genes coding for drug-transport proteins and metabolizing enzymes, amount of body fat, age, sex, patient compliance, diet or disease progression. LÄS MER