Sökning: "Dose-Response Relationship"

Visar resultat 31 - 35 av 111 avhandlingar innehållade orden Dose-Response Relationship.

1. 31. Pharmacokinetics and Pharmacodynamics of Anti-Cancer Regimens : Emphasis on Busulphan and the Combination Therapies Epirubicin-Docetaxel and Fluorouracil-Epirubicin-Cyclophosphamide

   Författare :Marie Sandström; Alison H Thomson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; Pharmacognosy; farmakognosi;

   Sammanfattning : Although the main reason for the lack of distinct dose-response and -toxicity relationships for anti-cancer agents is due to variability in pharmacodynamics, variability in pharmacokinetics may also contribute. Hence, not only describing and quantifying the relationship between pharmacokinetics and dose-limiting toxicities, but characterising the pharmacokinetics and its associated variability are of obvious importance in the process of developing dosing strategies for anti-cancer regimens. LÄS MER

3. 32. Contact allergy to colophony : clinical and experimental studies with emphasis on clinical relevance

   Författare :Gunilla Färm; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :colophony; contact allergy; gum rosin; laser Doppler flowmetry; LDF; pateh testing; repeated open application test; ROAT; rosin; tall-oil rosin; transepidermal water loss; TEWL; zinc oxide;

   Sammanfattning : Colophony - also called rosin - is a material obtained from coniferous trees. It is used widely in many products, particularly because of its good tackifying properties. Colophony is also used in paper sizing to increase water resistance. LÄS MER

4. 33. Pharmacometric Models for Individualisation of Warfarin in Adults and Children

   Författare :Anna-Karin Hamberg; Mia Wadelius; E Niclas Jonsson; Lena E Friberg; Jeffrey S Barrett; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; warfarin; pharmacokinetics; pharmacodynamics; pharmacometrics; pharmacogenetics; dose individualisation; children; Klinisk farmakologi; Clinical Pharmacology;

   Sammanfattning : Warfarin is one of the most widely used anticoagulants. Therapy is complicated by warfarin’s narrow therapeutic range and pronounced variability in individual dose requirements. Although warfarin therapy is uncommon in children, it is crucial for children with certain congenital or acquired heart diseases. LÄS MER

5. 34. Diet and sarcopenia risk in community-dwelling older European adults

   Författare :Diego Montiel Rojas; Fawzi Kadi; Elodie Ponsot; Andreas Nilsson; Rikard Landberg; Örebro universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Muscle mass; Muscle strength; Physical function; Healthy diet; Mediterranean diet; Macronutrients; Healthy ageing; Physical activity; Metabolic syndrome;

   Sammanfattning : The age-related decline in muscle strength and muscle mass can lead to sarcopenia with higher risk of falls, disability, and loss of independence. In this context, healthy dietary habits have the potential to delay onset of physical limitations, thereby promoting healthy ageing. LÄS MER

7. 35. Proton Relaxation Properties of a Particulate Iron Oxide MR Contrast Agent in Different Tissue Systems : Implications for Imaging

   Författare :Atle Bjørnerud; Graham A. Wright; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Iron oxide nanoparticles; USPIO; NC100150 Injection; water exchange limited relaxation; MR perfusion imaging.; Onkologi; Oncology; Onkologi; radiologi; Radiology;

   Sammanfattning : Knowledge of the relationship between in vivo contrast agent concentration and magnetic resonance (MR) signal response is an important requirement in contrast enhanced MR imaging in general and in MR based perfusion imaging in particular. This relationship is a complex function of the properties of the contrast agent as well as the structure of the target tissue. LÄS MER