Sökning: "Dose-Response Relationship"

Visar resultat 16 - 20 av 111 avhandlingar innehållade orden Dose-Response Relationship.

  1. 16. Single exposure phototesting and assessment of pigmented skin lesions : quantitative methods in terms of blood perfusion estimates

    Författare :Michail A. Ilias; Karin Wårdell; Stephan El Gammal; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : This thesis concerns the development of quantitative phototesting for the investigation of individual skin sensitivity to ultraviolet (UV) radiation, and the assessment of pigmented skin lesions (PSL) in terms of blood perfusion estimates. In both cases, laser Doppler perfusion imaging (LDPI) was used to quantify the perfusion. LÄS MER

  3. 17. Occupational exposure to polycyclic aromatic hydrocarbons and early biomarkers related to cardiovascular disease and cancer

    Författare :Ayman Alhamdow; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Polycyclic aromatic hydrocarbons (PAH) are omnipresent environmental pollutants composed of fused benzene rings and mainly produced by incomplete combustion of organic material. PAH exposure has been associated with increased risk of cancer and probably cardiovascular disease (CVD). LÄS MER

  4. 18. Early assessment of efficacy and safety of novel anticoagulants as exemplified by direct thrombin inhibitors. Non-clinical pharmacodynamic studies in vitro and in vivo

    Författare :Margareta Elg; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; animals; antidote; bleeding; inhibition constant; inogatran; association rate constant; melagatran; thrombin inhibitor; thrombosis; fibrinolysis;

    Sammanfattning : The drawbacks of today's anticoagulants are parenteral use (heparins), a narrow interval between efficacy and bleeding, and the high variability of effect with a consequent need for frequent monitoring (coumarins). The aim of the current studies was to evaluate properties important for efficacy and safety of novel anticoagulants, as exemplified by direct thrombin inhibitors, with non-clinical methods. LÄS MER

  5. 19. New modes of improving ventilation and oxygenation in pulmonary hypertension and acute respiratory failure in newborns and children

    Författare :Sylvia Göthberg; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Inhaled nitric oxide; high frequency oscillatory ventilation; partial liquid ventilation; respiratory inductive plethysmography; follow-up study; pulmonary hypertension; congenital heart disease; acute respiratory failure; respiratory distress syndrome; persistent pulmonary hypertension of the newborn.;

    Sammanfattning : Pulmonary hypertension leading to hypoxemia is a potentially life-threatening condition in pediatric intensive care. Hypoxemia may also result from conditions not primarily related to pulmonary hypertension. LÄS MER

  7. 20. I själ och hjärta - Psykosociala faktorer och hjärt-kärlhälsa

    Författare :Yvonne Natt och Dag; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Psychosocial epidemiology; Psychological distress; Psychosocial factors; Cardiovascular disease; Atherosclerosis;

    Sammanfattning : Cardiovascular disease (CVD) is the leading cause of death in Sweden and worldwide. Although the prevalence is declining in the Western world there are signs of rising prevalence among the young. LÄS MER