Sökning: "Dorsal Root Ganglia DRG"

Visar resultat 1 - 5 av 39 avhandlingar innehållade orden Dorsal Root Ganglia DRG.

1. 1. Studies on Peripheral Nerve Regeneration: Microdispensing, Neurite Guidance and Galectins

   Författare :Per Gustavsson; Funktionell zoologi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; vävnadskultur; histokemi; cytokemi; Histologi; tissue culture; histochemistry; cytochemistry; Histology; Schwann cells; sciatic nerve; dorsal root ganglia; DRG; neurite guidance; galectins; inkjet; microdispensing; peripheral nervous system; nerve regeneration; Animal physiology; Djurfysiologi; Biotechnology; Bioteknik;

   Sammanfattning : The present thesis describes development of a microdispenser-based technique to create of protein patterns for neurite guidance. The same technique was also developed to allow direct positioning of dissociated cells, including neurons, on cell culture substrates. Finally the role of galectin-3 and 8 during nerve regeneration was investigated. LÄS MER

3. 2. Effects of nucleus pulposus on nerve root circulation and function. Morphologic and functional studies in an experimental model using porcine spinal nerve roots

   Författare :Gunnar Byröd; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Nerve root; dorsal root ganglion; intervertebral disc; nucleus pulposus; epidural space; nerve fibre; permeability; blood flow; sciatica;

   Sammanfattning : Sciatica due to lumbar disc herniation has for many decades been viewed as a consequence of mechanical compression exerted on spinal nerve roots by the bulging disc tissues. Recent research has, however, indicated that extruded nucleus pulposus (NP) from the intervertebral disc might cause functional and endoneurial morphological changes in spinal nerve roots, without mechanical compression. LÄS MER

4. 3. Studies on pain-related messengers and receptors in dorsal root ganglia and spinal cord

   Författare :Malin Rydh-Rinder; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Pain is the most common reason why people seek medical advice. A large group of patients suffering from so-called neuropathic pain, due to injury to the nervous system itself, is often not helped by the currently available therapies. Classical analgesic drugs, such as opioids and non-steroidal anti-inflammatory drugs, may have severe side effects. LÄS MER

5. 4. Regeneration of Peripheral Nerves. The role of protein kinases, with emphasis on neurotrophic factor stimulation

   Författare :Peter Wiklund; Biologiska institutionen; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NT-4; NT-3; NGF; MAPK; PKG; PKA; PKC; nodose ganglion; DRG; conditioning effect; neurotrophic factors; protein kinases; peripheral; nerve regeneration; BDNF; GDNF; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

   Sammanfattning : The purpose of this study was to investigate the role of protein kinases in peripheral nerve regeneration, with the use of dorsal root ganglia (DRG) and nodose ganglia explants from adult mice. The effects of neurotrophic factor stimulation and protein kinase inhibition were studied for long (days) and short term (minutes) effects. LÄS MER

7. 5. Vascular Endothelial Growth Factor (VEGF) and Peripheral Nerve Regeneration

   Författare :Mariann Sondell; Biologiska institutionen; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Schwann cell; SCG; rat; peripheral nerve regeneration; neuropilin-1; nerve repair; mouse; growth factor; flk-1; axonal outgrowth; DRG; VEGF; Animal physiology; Djurfysiologi;

   Sammanfattning : This thesis concerns vascular endothelial growth factor (VEGF) and its possible role as a neurotrophic factor. I have investigated the effect of VEGF on neurons in culture but also in vivo, following a crush lesion of the sciatic nerve, and following nerve repair. LÄS MER