Sökning: "Discovery"

Visar resultat 16 - 20 av 1204 avhandlingar innehållade ordet Discovery.

  1. 16. Bioinformatics tools for discovery and evaluation of biomarkers : Applications in clinical assessment of cancer

    Författare :Benjamin Ulfenborg; Björn Olsson; Karin Klinga-Levan; Erik Larsson Lekholm; Högskolan i Skövde; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Algorithms; biomarkers; machine learning; classification; cancer; microRNA database; microRNA discovery; partial least squares; Medical sciences; Medicin; Bioinformatik; Bioinformatics; Biomedicin;

    Sammanfattning : Cancer is a disease characterized by abnormal proliferation of cells in the body and ranks as the second leading cause of death worldwide. In order to improve cancer patient care, a major focus of cancer research is to discover biomarkers. LÄS MER

  3. 17. Mistletoes and Thionins : as Selection Models in Natural Products Drug Discovery

    Författare :Sonny Larsson; Anders Backlund; Lars Bohlin; Peter J. Houghton; Uppsala universitet; []
    Nyckelord :Pharmacognosy; drug discovery; mistletoe; phylogeny; cytotoxic peptides; Santalales; Farmakognosi;

    Sammanfattning : The process of drug discovery from natural products starts with the selection of study object. In this project recent knowledge and methods are incorporated to investigate the process of such selection for pharmacognostic investigations. LÄS MER

  4. 18. Phenotypic antibody discovery and mining of complex antibody libraries

    Författare :Anne Ljungars; Institutionen för immunteknologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Antibody discovery; Phage display; Phenotypic screening; Cell selection; Deep mining; Complex phage pools;

    Sammanfattning : Therapeutic antibodies are the fastest growing class of drugs but suffer from a crowded target-space where many antibodies, against a few targets, are developed in parallel. The aim of this thesis is to find methods to enable discovery of novel antibody-target combinations and thereby increase the target-space. LÄS MER

  5. 19. Interaction Characteristics of Viral Protease Targets and Inhibitors : Perspectives for drug discovery and development of model systems

    Författare :Cynthia F Shuman; Jordan J N Tang; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; viral proteases; biomolecular interactions; kinetics; thermodynamics; biosensors; drug discovery; Biokemi; Biochemistry; Biokemi; Biokemi; Biochemistry;

    Sammanfattning : Viral proteases are important targets for anti-viral drugs. Discovery of protease inhibitors as anti-viral drugs is aided by an understanding of the interactions between viral protease and inhibitors. This thesis addresses the characterization of protease-inhibitor interactions for application to drug discovery and model system development. LÄS MER

  7. 20. A Further Step of Causal Discovery towards Real-World Impacts

    Författare :Ruibo Tu; Hedvig Kjellström; Cheng Zhang; Robin Evans; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; causal discovery; missing data; fairness; functional causal model; Datalogi; Computer Science;

    Sammanfattning : The goal of many sciences is to find causal relationships and understand underlying mechanisms. As the golden standard for finding causal relationships, doing randomized experiments can be difficult or impossible in some applications; hence, determining underlying causal relationships purely from observational data, i.e. LÄS MER