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Visar resultat 1 - 5 av 101 avhandlingar som matchar ovanstående sökkriterier.
1. Complement Activation Triggered by Biomaterial Surfaces : Mechanisms and Regulation
Sammanfattning : Today there are a vast number of medical devices in temporary or permanent contact with human tissues. Blood-biomaterial contact is known to trigger the complement system and results in generation of fluid phase anaphylatoxins C3a and C5a, and surface-bound C3b and iC3b. LÄS MER
2. Rules of engagement - Regulation of complement response in tissue
Sammanfattning : Always in motion and probing for danger, complement proteins are found in every space and notch of the body. Their omnipresence combined with an ability to wreak havoc when activated, mandates a strong leash! The how, when, and where to unleash or constrain the complement response remain partly answered questions, despite the significant progress made in the field in the past 100 years. LÄS MER
3. Antibody Feedback Regulation and T Cells
Sammanfattning : Antibodies, passively administered or actively produced, regulate immune responses to the antigen they recognize. This phenomenon is called antibody-mediated feedback regulation. Feedback regulation can be positive or negative, resulting in >1000-fold enhancement or >99% suppression of the specific antibody response. LÄS MER
4. Interactions between platelets and complement with implications for the regulation at surfaces
Sammanfattning : Disturbances of host integrity have the potential to evoke activation of innate immunologic and hemostatic protection mechanisms in blood. Irrespective of whether the activating stimulus is typically immunogenic or thrombotic, it will generally affect both the complement system and platelets to a certain degree. LÄS MER
5. Novel endogenous mechanisms of complement regulation - A delicate balance
Sammanfattning : In this thesis, the biochemical mechanisms for complement activation by endogenous proteins are explored. The short leucine-rich repeat proteins (SLRPs) help organise extracellular matrices. We found that several SLRPs bind C1q and of these, fibromodulin and osteoadherin trigger complement. LÄS MER