Sökning: "Amyloid Beta"

Visar resultat 36 - 40 av 172 avhandlingar innehållade orden Amyloid Beta.

1. 36. Pancreatic extracellular communication. Applications to beta cell cultures and islet amyloid polypeptide aggregation

   Författare :Diana Ribeiro; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; in vitro pancreatic models; induced pluripotent stem cells; stem cell differentiation; insulin; 3D-culture; extracellular vesicles; glucose-stimulated insulin secretion; islet amyloid polypeptide; type 2 diabetes mellitus; extracellular matrix; adipose-derived stem cells; Diabetes mellitus; protein aggregation;

   Sammanfattning : Diabetes mellitus (DM) is a disease with epidemic proportions due to increased incidences worldwide, persistence of undiagnosed cases, uncontrolled forms of the disease, association with cardiovascular complications, and lack of definitive treatment options. In particular, type 2 DM (T2DM) is placing an enormous financial burden on worldwide healthcare systems that will increase in the futureThere is a need to develop physiological assay platforms that provide functionally relevant models of diabetes in order to accelerate the discovery of new treatments. LÄS MER

3. 37. Development of new affinity proteins for neurodegenerative disorders

   Författare :Linnea C. Hjelm; John Löfblom; Stefan Ståhl; Hanna Lindberg; Ylva Ivarsson; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Protein engineering; sequestrins; amyloid beta; alpha-synuclein; phage display; affibodies; blood–brain barrier; Transferrin receptor; receptor-mediated transcytosis; recombinant spider silk; Biotechnology; Bioteknologi;

   Sammanfattning : Neurodegenerative disorders include a full spectrum of diagnoses, including dementias and other neuronal diseases, characterised by degradation of neurons in the brain occurring along with disease progression. Amongst the dementias, the most prevalent are Alzheimer’s (AD) and Parkinson’s disease (PD) that affect millions of people worldwide. LÄS MER

4. 38. Fluorescent Probes and Protein Misfolding: Methods and Applications

   Författare :Irem Nasir; Biokemi och Strukturbiologi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Protein misfolding; fluorophores; filter-trap; site-specific fluorophore labeling; amyloid-beta; microscopic rate constants; solvatochromic probes; alpha-synuclein; lipid vesicles; nanoparticles; protein adsorption;

   Sammanfattning : Protein misfolding is a frequently occurring event in living cells and without the quality control, the consequences are disasterous. In this thesis, we studied protein misfolding in vitro by employing a variety of fluorophores, to either detect the highly ordered aggregates of intrinsically disordered proteins/peptides or slight misfolding of a natively folded protein. LÄS MER

5. 39. On the nature of mixed neurodegenerative amyloidopathies

   Författare :Nadja Gustavsson; NanoLund: Centre for Nanoscience; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin och hälsovetenskap; Parkinson s disease PD ; Alzheimers disease AD ; Amyloidosis; Alpha synuclein; Amyloid beta;

   Sammanfattning : Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common neurodegenerative diseases in the world. It has been possible to identify common denominators for AD and PD, including aggregation of the amyloid proteins amyloid-beta (Aβ) and alpha-synuclein (α-syn). LÄS MER

7. 40. Clinical Consequences of Axonal Injury in Traumatic Brain Injury

   Författare :Sami Abu Hamdeh; Niklas Marklund; Per Enblad; Lars Hillered; Andreas PhD Unterberg MD; Uppsala universitet; []
   Nyckelord :Traumatic brain injury; diffuse axonal injury; intracranial pressure; magnetic resonance imaging; amyloid-beta; tau; Neurokirurgi; Neurosurgery;

   Sammanfattning : Traumatic brain injury (TBI), mainly caused by road-traffic accidents and falls, is a leading cause of mortality. Survivors often display debilitating motor, sensory and cognitive symptoms, leading to reduced quality of life and a profound economic burden to society. LÄS MER