Sökning: "Amyloid Beta"
Visar resultat 41 - 45 av 172 avhandlingar innehållade orden Amyloid Beta.
41. Preclinical PET imaging and therapy of Alzheimer's disease
Sammanfattning : The main histopathological hallmarks of Alzheimer’s disease are extracellular amyloid-beta (Aβ) plaques and intracellular neurofibrillary tangles, containing tau protein. Because of misfolded and aggregated proteins, activated microglia and astroglia react with a neuroinflammatory response, which may contribute to disease progression and severity. LÄS MER
42. Stress steroids as accelerators of Alzheimer's disease. : Effects of chronically elevated levels of allopregnanolone in transgenic AD models
Sammanfattning : Background Alzheimer’s disease (AD) and dementia are devastating conditions not only for the affected patients but also for their families. The economical costs for the society are tremendous. LÄS MER
43. Mutational effects on protein structure and function
Sammanfattning : In this thesis several important proteins are investigated from a structural perspective. Some of the proteins are disease related while other have important but not completely characterised functions. LÄS MER
44. The choreography of protein vibrations : Improved methods of observing and simulating the infrared absorption of proteins
Sammanfattning : The work presented in this thesis has striven toward improving the capability to study proteins using infrared (IR) spectroscopy. This includes development of new and improved experimental and theoretical methods to selectively observe and simulate protein vibrations. LÄS MER
45. Developing a Porcine Model to Study the Glymphatic System
Sammanfattning : The glymphatic system is a brain-wide solute clearance system that has developed in the brain to clear metabolic waste during sleep. This clearance is mediated by advective fluxes of cerebrospinal fluid (CSF) along perivascular spaces (PVS) and through the brain. LÄS MER