Sökning: "voltage gated potassium channel"

Visar resultat 16 - 20 av 25 avhandlingar innehållade orden voltage gated potassium channel.

1. 16. Roles of unconventional ion channels and insulin granule structure in the pathogenesis of type-2 diabetes

   Författare :Mohammad Barghouth; Diabetes - öpatofysiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; T2D; pancreatic islets; mechanosensitive channels; Piezo1; beta-cell specific Piezo1 knockout mouse; KATP channel; dSTORM; Piezo1; Cav3.2; AQP1; SD; RRP; Insulin secretion and action;

   Sammanfattning : T2D is the most widespread endocrine disease. In conventional stimulus secretion coupling increased blood glucose is metabolized causing an increased intracellular level of ATP and closure of the KATP channels, and this, in turn, depolarizes the cell membrane leading to the opening of voltage-gated Ca2+ channels, the influx of Ca2+ and exocytosis of insulin granules. LÄS MER

3. 17. Megencephaly, significance, biology and identification of a genetic cause

   Författare :Susanna Petersson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Megalencephaly; brain; mceph; ion-channel; DNA; mutation; truncation; frameshift; seizure; plasticity; neurotrophin; growth factor; neuropeptide; positional cloning;

   Sammanfattning : Enlarged brain is termed megencephaly or megalencephaly, and is defined as a brain volume above the 98th percentile. It is a major sign in several neurological diseases with symptoms ranging from very mild to lethal, including mental retardation, low intelligence, motoric and neurological disturbances, seizures and dysmorphic features. LÄS MER

4. 18. Mechanisms of adaptation in a mechanoreceptor : a study of mechanical and ionic factors in the crayfish stretch receptors

   Författare :Nuhan Purali; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Crayfish; stretch receptor; adaptation; visco-elastic properties; mechanosensitive channels; potassium channels; sodium channels; gadolinium; tetraethylammonium chloride; 4-amino pyridine; scorpion venom Leiurus quinquestrialus;

   Sammanfattning : The stretch receptor organ of the crayfish, an analog to the human muscle spindle, is a unique preparation for the study of mechanotransduction. The organ consists of a rapidly and a slowly adapting receptor each composed of a receptor muscle fibre into which inserts the dendrites of a multipolar sensory neuron. LÄS MER

5. 19. Molecular mechanisms of modulation of KV7 channels by polyunsaturated fatty acids and their analogues

   Författare :Johan Larsson; Sara Liin; Fredrik Elinder; Maurizio Taglialatela; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : Ion channels are membrane proteins that regulate the permeability of ions across the cell membrane. The sequential opening of different types of ion channels produces action potentials in excitable cells. Action potentials are a way for the body to, for example, transmit signals quickly over a long distance. LÄS MER

7. 20. Deciphering conformational ensembles and communication pathways in biomolecules

   Författare :Annie M. Westerlund; Lucie Delemotte; Erik Lindahl; Kresten Lindorff-Larsen; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular dynamics; Clustering; Machine learning; Network analysis; Calmodulin; KCNQ1; Biological Physics; Biologisk fysik;

   Sammanfattning : Life is constructed by small building blocks called cells. Proteins are the biomolecules within these cells which carry out different functions. Proteins located in the cell membrane, for example, allow for the transport of ions and small molecules, as well as communication, across the cell membrane. LÄS MER