Sökning: "mechanosensitive channels"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden mechanosensitive channels.

  1. 1. Thermo- and chemosensitive properties of Transient Receptor Potential Ankyrin 1 ion channels

    Författare :Lavanya Moparthi; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TRP ion channels; TRPA1; ankyrin repeat domain; thermosensation; chemosensation; cold sensor; electrophiles; non-electrophiles; planar lipid bilayers; patch-clamp; fluorescence spectroscopy; mass spectrometry;

    Sammanfattning : The ability to sense and accommodate to an ever-changing environment is crucial for the survival of living organisms. Transient Receptor Potential (TRP) ion channels comprise a large superfamily of cation conducting membrane proteins that function as molecular sensors in diverse sensory processes including perception of light, taste, smell, sound, touch and temperature. LÄS MER

  3. 2. Environmental input to the pancreatic β-cells - the role of mechanosensitive and other ion channels

    Författare :Ye Yingying; Diabetes - öpatofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; T2D; pancreatic islets; mechanosensitive channels; Piezo1; beta-cell specific Piezo1 knockout mouse; Tcf7l2; alpha2delta-1; MafA; gamma4; beta-cell function; insulin secretion; dedifferentiation; Ca2 signaling; transcription factor;

    Sammanfattning : Compound input from genetic predisposition, environmental factors and lifestyle lead to beta-cell dysfunction which initiates the development of type 2 diabetes. Understanding the linkage between the environmental input and gene regulatory pathways controlling beta-cell function is key for developing novel therapies against T2D. LÄS MER

  4. 3. Expression and function of TRP channels in peripheral sensory neurons

    Författare :Susanne Staaf; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Transient receptor potential (TRP) channels comprise a family of multifunctional proteins which has since its discovery been of particular interest in sensory biology even though they are also frequently expressed in non-neuronal cell types. It is evident that TRP channels play an important role in the function of sensory neurons, not at least by being sensors of external stimuli. LÄS MER

  5. 4. Roles of unconventional ion channels and insulin granule structure in the pathogenesis of type-2 diabetes

    Författare :Mohammad Barghouth; Diabetes - öpatofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; T2D; pancreatic islets; mechanosensitive channels; Piezo1; beta-cell specific Piezo1 knockout mouse; KATP channel; dSTORM; Piezo1; Cav3.2; AQP1; SD; RRP; Insulin secretion and action;

    Sammanfattning : T2D is the most widespread endocrine disease. In conventional stimulus secretion coupling increased blood glucose is metabolized causing an increased intracellular level of ATP and closure of the KATP channels, and this, in turn, depolarizes the cell membrane leading to the opening of voltage-gated Ca2+ channels, the influx of Ca2+ and exocytosis of insulin granules. LÄS MER

  7. 5. Mechanisms of adaptation in a mechanoreceptor : a study of mechanical and ionic factors in the crayfish stretch receptors

    Författare :Nuhan Purali; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Crayfish; stretch receptor; adaptation; visco-elastic properties; mechanosensitive channels; potassium channels; sodium channels; gadolinium; tetraethylammonium chloride; 4-amino pyridine; scorpion venom Leiurus quinquestrialus;

    Sammanfattning : The stretch receptor organ of the crayfish, an analog to the human muscle spindle, is a unique preparation for the study of mechanotransduction. The organ consists of a rapidly and a slowly adapting receptor each composed of a receptor muscle fibre into which inserts the dendrites of a multipolar sensory neuron. LÄS MER