Sökning: "T2D"

Visar resultat 1 - 5 av 168 avhandlingar innehållade ordet T2D.

  1. 1. Beta Cell Function: from Human Genetics to Animal Models

    Författare :Martins Kalis; Diabetes - immunovirologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; animal model; Dicer1; genetics; genetic association; single nucleotide polymorphism; SNP; INS-1E; AAT; FOXP3; beta cell function; insulin secretion; FFAR1; insulin; T2D; glucose; T1D;

    Sammanfattning : Beta cell function is an important factor in the development of both Type 1 (T1D) and Type 2 (T2D) diabetes mellitus. T1D is characterized by a primary defect in insulin secretion due to the immune-mediated beta cell destruction, however, the more common T2D beside insulin resistance also include impaired beta cell function as a consequence to abnormal glucose homeostasis. LÄS MER

  3. 2. The role of CART in islet function

    Författare :Mia Abels; Neuroendokrin cellbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cocaine- and amphetamine-regulated transcript; CART; Diabetes; T2D; Human islets; Glucagon; Insulin; Adipocyte;

    Sammanfattning : Diminished insulin secretion and dysregulated glucagon secretion are key features of type 2 diabetes (T2D). The overall aim of this thesis was to study the role of cocaine- and amphetamine-regulated transcript (CART) in islet cell function and how CART regulates glucose homeostasis. LÄS MER

  4. 3. Image-based multi-omics data integration : Exploring whole-body PET/MRI, -omics data and body composition

    Författare :Robin Visvanathar; Håkan Ahlström; Joel Kullberg; Jan Eriksson; Katrine Riklund; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Body composition; Imiomics; genomics; metabolomics; MRI; PET; insulin sensitivity; T2D;

    Sammanfattning : Advanced body composition analysis with whole-body imaging could uncover novel associations between regional tissue composition and metabolic disease. Imiomics is an automated image analysis framework that enables large-scale integration of magnetic resonance imaging (MRI) data and orthogonal technologies such as metabolomics and genomics for the detailed study of body composition. LÄS MER

  5. 4. Studies in beta cells and adipocytes in the context of obesity and T2D - focusing on PDE3B, OPN and SCFAs

    Författare :Emilia Heimann; Signaltransduktionsforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obesity; type 2 diabetes; islets of Langerhans; adipocytes; PDE3B; OPN; SCFAs;

    Sammanfattning : Type 2 diabetes (T2D) is a heterogeneous disease characterized by altered lipid parameters and elevated glucose levels, as a direct consequence of impaired insulin signaling in target tissues and reduced insulin exocytosis from pancreatic β-cells. Obesity, which dramatically increases worldwide, is associated with insulin resistance and T2D. LÄS MER

  7. 5. Data integration and visualization in type 2 diabetes research and care: From biological mechanisms to precision medicine

    Författare :Olof Asplund; diabetes och endokrinologi Genomik; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Type 2 diabetes T2D ; human pancreatic islets; human skeletal muscle; transcriptomics; genomics; phenomics; ANDIS; diabetes; diabetics;

    Sammanfattning : Background. Type 2 diabetes (T2D) is a complex heterogeneous disorder affecting multiple organs. Gene expression studies in organs central to T2D, such as pancreatic islets and skeletal muscle will help elucidate and disentangle molecular mechanisms underlying T2D. LÄS MER