Sökning: "AQP1"

Visar resultat 1 - 5 av 13 avhandlingar innehållade ordet AQP1.

  1. 1. Roles of unconventional ion channels and insulin granule structure in the pathogenesis of type-2 diabetes

    Författare :Mohammad Barghouth; Diabetes - öpatofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; T2D; pancreatic islets; mechanosensitive channels; Piezo1; beta-cell specific Piezo1 knockout mouse; KATP channel; dSTORM; Piezo1; Cav3.2; AQP1; SD; RRP; Insulin secretion and action;

    Sammanfattning : T2D is the most widespread endocrine disease. In conventional stimulus secretion coupling increased blood glucose is metabolized causing an increased intracellular level of ATP and closure of the KATP channels, and this, in turn, depolarizes the cell membrane leading to the opening of voltage-gated Ca2+ channels, the influx of Ca2+ and exocytosis of insulin granules. LÄS MER

  3. 2. Expression and hormonal regulation of aquaporins in the human uterus

    Författare :Anna Hildenbrand Wachtmeister; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : BACKGROUND: Aquaporins (AQPs) are water channels present in the cell wall, allowing water – and occasionally other molecules – to pass the cell membrane. So far 13 AQPs have been found in humans. Their function is to maintain the cell internal milieu by regulating water and ion equilibrium. LÄS MER

  4. 3. Water transport through perinatal skin : Barrier function and aquaporin water channels

    Författare :Johan Ågren; Gunnar Sedin; Gunnar Flemström; Steven B Hoath; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pediatrics; Preterm infant; Transepidermal water loss; Aquaporin; Skin biology; Hyperosmolarity; Pediatrik; Paediatric medicine; Pediatrisk medicin; pediatrik; Pediatrics;

    Sammanfattning : While constituting a well functioning interface with the aqueous environment in utero, the skin offers a poor barrier after very preterm birth. As a result, transepidermal water loss (TEWL) is high, a fact which has important clinical consequences in these infants. LÄS MER

  5. 4. Expression and Function of Human and Plant Aquaporins

    Författare :Maria Agemark; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; aquaporin; water channel; overexpression; Pichia pastoris; AQP8; AQP5; SoPIP2; 1;

    Sammanfattning : The aquaporins (AQPs) belong to a family of water permeable membrane channels found in virtually all living organisms. Thirteen isoforms of mammalian AQPs are found, whereas in Arabidopsis thaliana 35 genes encoding AQPs are found. The AQPs are distributed in different organs, cell types and in different subcellular membranes. LÄS MER

  7. 5. Marginally hydrophobic transmembrane α-helices shaping membrane protein folding

    Författare :Tuuli Minttu Virkki de Marothy; Arne Elofsson; William Dowhan; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; membrane protein folding; hydrophobicity; translocon; transmembrane helix; marginally hydrophobic transmembrane helices; orientational preference; positive inside rule; aquaporin 1; Biochemistry; biokemi;

    Sammanfattning : Most membrane proteins are inserted into the membrane co-translationally utilizing the translocon, which allows a sufficiently long and hydrophobic stretch of amino acids to partition into the membrane. However, X-ray structures of membrane proteins have revealed that some transmembrane helices (TMHs) are surprisingly hydrophilic. LÄS MER