Sökning: "voltage gated potassium channel"

Visar resultat 11 - 15 av 25 avhandlingar innehållade orden voltage gated potassium channel.

1. 11. Role of potassium channels in regulating neuronal activity

   Författare :Göran Klement; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Potassium channels; threshold dynamics; trafficking; hERG; SMOCs; excitability;

   Sammanfattning : The firing behaviour of excitable cells is fundamental for the information processing in multicellular organisms, varying from single spikes to different forms of repetitive firing. Of the many regulators, voltage gated potassium channels play a major role. In this thesis some aspects of the potassium channel regulation of firing are explored. LÄS MER

3. 12. Molecular Mechanisms of Resin Acids and Their Derivatives on the Opening of a Potassium Channel

   Författare :Nina Ottosson; Fredrik Elinder; David Engblom; Bertil Hille; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : Voltage-gated ion channels play fundamental roles in excitable cells, such as neurons, where they enable electric signaling. Normally, this signaling is well controlled, but brain damage, alterations in the ionic composition of the extracellular solution, or dysfunctional ion channels can increase the electrical excitability thereby causing epilepsy. LÄS MER

4. 13. Voltage sensor movements in shaker and HCN channels

   Författare :Roope Männikkö; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Voltage-gated ion channels are crucial for electrical signaling in living organisms. They are composed of four similar subunits with six transmembrane α-helices, S1-S6. Each subunit contains a voltage-sensing domain, S1-S4, and an ion-conducting pore domain, S5-S6. LÄS MER

5. 14. The megencephaly mouse : from gene to neuronal proliferation

   Författare :Ann-Sophie Persson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Megalencephaly; epilepsy; mouse model; genetics; voltage gated potassium channel; hippocampus; proliferation;

   Sammanfattning : Megalencephaly, enlarged brain, can be associated with a wide range of symptoms from benign to severe. Severe cases are often associated with mental retardation and seizures. The megencephaly mouse shows a dramatic, progressive increase in size of the hippocampus and ventral cortex. LÄS MER

7. 15. K+ channels in the inner ear : electrophysiological and molecular studies

   Författare :Guihua Liang; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Cochlea; gene expression; hair cell; immunohistochemistry; KCNQ; lead; M current; mercury; patch clamp; RT-PCR; voltage-gated potassium channels;

   Sammanfattning : Potassium channels are involved in several fundamental cellular processes. Heavy metals, such as mercury and lead, are widespread toxic pollutants and have been shown to act on various ion channels in the central nervous system. LÄS MER