Sökning: "virulence"
Visar resultat 36 - 40 av 464 avhandlingar innehållade ordet virulence.
36. Drosophila-Serratia as a host-parasite system : defence mechanisms and virulence factors
Sammanfattning : .... LÄS MER
37. Synthesis and functionalization of ring-fused 2-pyridones : Targeting pili formation in E. coli
Sammanfattning : Bicyclic dihydrothiazolo fused 2-pyridones have been studied as a new class of antibacterial agents, termed pilicides, that target the formation of adhesive bacterial surface organelles (pili) in pathogenic bacteria. Synthetic methods to further functionalize the bicyclic 2-pyridone scaffold have been developed in order to increase water-solubility and thereby facilitate biological evalua-tions. LÄS MER
38. Host-parasite interaction in men with febrile urinary tract infection
Sammanfattning : In a retrospective study, Escherichia coli isolates from 88 men with symptomatic urinary tract infection (UTI) were analysed. A wide array of O:K:H serotypes commonly associated with acute pyelonephritis in women were identified. LÄS MER
39. Peptidomimetics based on ring-fused 2-pyridones : probing pilicide function in uropathogenic E. coli and identification of Aβ-peptide aggregation inhibitors
Sammanfattning : This thesis describes the synthesis and biological evaluation of highly substituted, ring-fused 2-pyridones. The utility of the bicyclic 2-pyridones to gain fundamental insights into the disease processes of bacterial infections and Alzheimer’s disease has been investigated. LÄS MER
40. Pilicides and Curlicides : Design, synthesis, and evaluation of novel antibacterial agents targeting bacterial virulence
Sammanfattning : New strategies are needed to counter the growing problem of bacterial resistance to antibiotics. One such strategy is to design compounds that target bacterial virulence, which could work separately or in concert with conventional bacteriostatic or bactericidal antibiotics. LÄS MER
