Sökning: "acylketene"

Hittade 1 avhandling innehållade ordet acylketene.

  1. 1. Synthesis and functionalization of ring-fused 2-pyridones : Targeting pili formation in E. coli

    Författare :Nils Pemberton; Fredrik Almqvist; Oliver Kappe; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; 2-pyridone; acylketene; antibacterial; biofilm inhibitor; Mannich; Micro-wave-assisted chemistry; peptidomimetic; virulence.; Organic synthesis; Organisk syntes;

    Sammanfattning : Bicyclic dihydrothiazolo fused 2-pyridones have been studied as a new class of antibacterial agents, termed pilicides, that target the formation of adhesive bacterial surface organelles (pili) in pathogenic bacteria. Synthetic methods to further functionalize the bicyclic 2-pyridone scaffold have been developed in order to increase water-solubility and thereby facilitate biological evalua-tions. LÄS MER