Sökning: "curli"

Visar resultat 1 - 5 av 18 avhandlingar innehållade ordet curli.

1. 1. Contact activation on bacterial surfaces - a virulence mechanism

   Författare :Kristin Persson; Infektionsmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; General biomedical sciences; Biomedicinska vetenskaper allmänt ; sepsis; infection; S. aureus; S. typhimurium; E. coli; curli; fibrinopeptides; fibrinogen; Coagulation; contact system;

   Sammanfattning : Life-threatening conditions from bacterial infections are a major clinical problem. During a severe infection, the host responds by a massive release of pro-inflammatory mediators together with a systemic activation of systems such as the coagulation, fibrinolytic, and complement systems. LÄS MER

3. 2. Synthesis of substituted Ring-Fused 2-Pyridones and applications in chemical biology

   Författare :Christoffer Bengtsson; Fredrik Almqvist; Paul Helquist; Umeå universitet; []
   Nyckelord :Synthesis; 2-pyridone; 2-thiazoline; cross coupling; pili; curli; antibacterial; organisk kemi; Organic Chemistry;

   Sammanfattning : Antibiotics have been extensively used to treat bacterial infections since Alexander Fleming’s discovery of penicillin 1928. Disease causing microbes that have become resistant to antibiotic drug therapy are an increasing public health problem. LÄS MER

4. 3. Pilicides and Curlicides : Design, synthesis, and evaluation of novel antibacterial agents targeting bacterial virulence

   Författare :Erik Chorell; Fredrik Almqvist; Stephen Hanessian; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pilicide; curlicide; anti-virulence; chaperone usher pathway; antibacterial; pili; curli; Escherichia coli; biofilm inhibitor; 2-pyridone; peptidomimetic; Organic chemistry; Organisk kemi; Bioorganic chemistry; Bioorganisk kemi; Pharmaceutical chemistry; Läkemedelskemi; Organic synthesis; Organisk syntes; Infectious diseases; Infektionssjukdomar; Biorganic Chemistry; bioorganisk kemi; Infectious Diseases; infektionssjukdomar; datorlingvistik; computational linguistics; organisk kemi; Organic Chemistry;

   Sammanfattning : New strategies are needed to counter the growing problem of bacterial resistance to antibiotics. One such strategy is to design compounds that target bacterial virulence, which could work separately or in concert with conventional bacteriostatic or bactericidal antibiotics. LÄS MER

5. 4. Macromolecular Matchmaking : Mechanisms and Biology of Bacterial Small RNAs

   Författare :Erik Holmqvist; E. Gerhart H. Wagner; Udo Bläsi; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Small RNA; sRNA; non-coding RNA; antisense; gene regulation; post-transcriptional regulation; translational control; outer membrane protein; OmpA; MicA; biofilm; flagella; curli; bistability; Lrp; MicF; CsgD; FlgM; OmrA; OmrB; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology;

   Sammanfattning : Cells sense the properties of the surrounding environment and convert this information into changes in gene expression. Bacteria are, in contrast to many multi-cellular eukaryotes, remarkable in their ability to cope with rapid environmental changes and to endure harsh and extreme milieus. LÄS MER

7. 5. Nucleator-driven assembly of curli organelles and their pathophysiological role in E. coli septic shock

   Författare :Zhao Bian; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Assembly; Curli; NOS2; Nucleator; Sepsis;

   Sammanfattning : The understanding of how polymeric surface structures are assembled in bacteria is one of general interests, which can provide insight into details of macromolecule interactions, and study how proteins fold into domains as assembly modules for building organelles. Protein-protein interactions in various subcellular compartments lead to the assembly of fimbriae at bacterial cell surfaces. LÄS MER