Sökning: "Mannich"
Visar resultat 1 - 5 av 12 avhandlingar innehållade ordet Mannich.
1. Synthesis and functionalization of ring-fused 2-pyridones : Targeting pili formation in E. coli
Sammanfattning : Bicyclic dihydrothiazolo fused 2-pyridones have been studied as a new class of antibacterial agents, termed pilicides, that target the formation of adhesive bacterial surface organelles (pili) in pathogenic bacteria. Synthetic methods to further functionalize the bicyclic 2-pyridone scaffold have been developed in order to increase water-solubility and thereby facilitate biological evalua-tions. LÄS MER
2. Asymmetric Organocatalytic Aldol and Mannich Reactions Catalyzed by Amino Acid-Derivatives and Small Peptides with a Primary Amine Functionality
Sammanfattning : .... LÄS MER
3. Amino acid-catalyzed synthesis of amino acid derivatives : Application and semi-synthesis of Paclitaxel, Docetaxel and their derivatives
Sammanfattning : This thesis deals with different applications of organocatalysis, where amino acid derivatives and small peptides are applied as catalysts. First, the development of environmentally friendly aldol reactions, carried out in aqueous media is illustrated. The corresponding β-hydroxy ketones are formed with ee´s up to 99%. LÄS MER
4. Design & Synthesis of Protein Interacting Affinity Ligands and Protease Inhibitors
Sammanfattning : There is a growing need of both protein drugs and synthetic drugs in the fight against many life-threatening diseases. The first part of this thesis deals with the design and synthesis of high affinity binding ligands for the purification of protein drugs. LÄS MER
5. Physical, Chemical and Biochemical Modifications of Industrial Softwood Kraft Lignin for Different Applications
Sammanfattning : Various technical lignins, e.g. industrial Softwood Kraft lignin (SKL), are now largely available while they are generally underutilized due to their heterogeneous and complicated structures and/or the poor properties. LÄS MER
