Avancerad sökning
Visar resultat 1 - 5 av 17 avhandlingar som matchar ovanstående sökkriterier.
1. Notch Signaling in Human Neuroblastoma Cells
Sammanfattning : Neuroblastoma is a childhood tumor derived from the sympathetic nervous system (SNS). It is believed that the tumors arise from cells halted in their differentiation and due to their immature phenotype; they express proteins normally only detected during embryogenesis. One such protein is Hash-1, which is required for formation of the SNS. LÄS MER
2. Transcriptomics and Proteomics Applied to Developmental Toxicology
Sammanfattning : Developmental toxicology is an important part of preclinical drug toxicology as well as environmental toxicology. Assessing reproductive and developmental toxicity is especially expensive and time demanding, since at least two generations of animals are needed in the tests. LÄS MER
3. Notch Signaling in Neuroblastoma and Renal Cell Carcinoma
Sammanfattning : The Notch signaling pathway governs cell functions essential for normal development and organogenesis. Aberrant Notch signaling has been implicated in tumorigenesis by perturbing control of proliferation, differentiation, apoptosis, migration and angiogenesis. LÄS MER
4. Pluripotent Stem Cells of Embryonic Origin : Applications in Developmental Toxicology
Sammanfattning : General toxicity evaluation and risk assessment for human exposure is essential when developing new pharmaceuticals and chemicals. Developmental toxicology is an important part of this risk assessment which consumes large resources and many laboratory animals. LÄS MER
5. Pharmacological stimulation of endothelial function and long-term impact of hypertension in man
Sammanfattning : Background: Ischemic heart disease is a major cause of death globally. Rupture of a coronary atherosclerotic plaque with occluding thrombus formation is the main cause of myocardial ischemia and infarction. LÄS MER