Sökning: "TGF-alpha"
Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet TGF-alpha.
1. Studies of transforming growth factor alpha in normal and abnormal growth
Sammanfattning : Regulation of growth is of fundamental importance for development of the organism and to maintain health. The induction of cell proliferation and matrix production are influenced by several different signaling systems, most importantly by growth factors. LÄS MER
2. Notch Signaling in Human Neuroblastoma Cells
Sammanfattning : Neuroblastoma is a childhood tumor derived from the sympathetic nervous system (SNS). It is believed that the tumors arise from cells halted in their differentiation and due to their immature phenotype; they express proteins normally only detected during embryogenesis. One such protein is Hash-1, which is required for formation of the SNS. LÄS MER
3. Gene expression in the dorsal root ganglion and the role of PAI-1 and amphiregulin during regeneration
Sammanfattning : This thesis is concerned with two aspects of peripheral nerve injury. First the early changes in the gene expression of the dorsal root ganglion (DRG) in response to sciatic nerve injury as revealed by micro-array analysis. Second an examination of the effect of PAI-1 and amphiregulin on survival and axonal outgrowth from DRG. LÄS MER
4. Paracrine regulation of Sertoli cell proliferation
Sammanfattning : The Sertoli cell is a highly differentiated somatic cell in the seminiferous epithelium of the testis. This cell is of prime importance for both testicular development and spermatogenesis. LÄS MER
5. On the regulation and effects of chronic inflammation in inflammatory bowel disease
Sammanfattning : Inflammatory bowel disease is thought to result from the inappropriate and ongoing activation of the mucosal immune system driven by the presence of normal luminal flora. In this process monocytes/macrophages contribute to and maintain chronic inflammation by being both regulatory and effector cells. LÄS MER