Sökning: "tumor necrosis factor inhibition"

Visar resultat 11 - 15 av 32 avhandlingar innehållade orden tumor necrosis factor inhibition.

1. 11. Regulation of apoptotic processes in neurodegeneration and cancer : In vitro studies on human neuroblastoma cells

   Författare :Tom Gatsinzi; Kerstin Iverfeldt; Thomas J. Sayers; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Sammanfattning : Apoptosis is a highly controlled process of cell death, which is vital for maintenance of all multicellular organisms. Aberrant regulation of apoptosis can give rise to pathological conditions such as neurodegenerative diseases and cancer. LÄS MER

3. 12. Diabetic Vascular Complications & Inflammation - role of NFAT and TNFalpha

   Författare :Jenny Öhman; Kardiovaskulär forskning - immunitet och ateroskleros; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; vascular; hyperglycemia; osteopontin; NFAT; diabetes; retinopathy; TNF; UTP;

   Sammanfattning : Vascular complications of diabetes account for the majority of morbidity and mortality among diabetic patients. Large clinical trials have identified hyperglycemia as a risk factor in the development of diabetic vascular complications. LÄS MER

4. 13. Intestinal ischemia and reperfusion. Proinflammatory response and organ dysfunction

   Författare :Knut Olanders; Lund Institutionen för kliniska vetenskaper; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; traumatology; Kirurgi; ortopedi; traumatologi; orthopaedics; Surgery; inflammation; cytokine; leukocyte; reperfusion; ischemia; permeability; Intestine; endothelium;

   Sammanfattning : Intestinal I/R is considered to be an important initiating event in several pathophysiological conditions such as trauma, bleeding, sepsis and pancreatitis, frequently leading to concomitant both single and potentially multiple organ dysfunction. The purpose of this thesis was to study mechanims underlying the development of multiple organ dysfunction, with special focus on intercellular proinflammatory regulation in the concurrent development of tissue injury. LÄS MER

5. 14. Immunogenicity of and apoptosis modulation by Epstein-Barr virus (EBV)-encoded latent membrane protein-1 (LMP1) : implications for nasopharyngeal carcinoma

   Författare :Xiangning Zhang; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus which infects more than 90% of individuals in the population, and has been shown to be associated with a variety of human tumors. The viral genome encodes a number of transforming proteins which enable the virus to efficiently immortalize B lymphocyte and also transform cells of other types. LÄS MER

7. 15. The gut-brain axis in Parkinson’s disease : epidemiological studies on causes, underlying mechanisms and novel treatments

   Författare :Xiaoying Kang; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Parkinson’s disease (PD) is an age-related neurodegenerative disease with highly heterogeneous symptomatology. Little is known about why PD occurs. The gastrointestinal tract has been postulated as an origin of PD pathology, which then spreads along the gut- brain axis to enter the brain. LÄS MER