Sökning: "tumor necrosis factor inhibition"

Visar resultat 21 - 25 av 32 avhandlingar innehållade orden tumor necrosis factor inhibition.

  1. 21. Cytokines and cytokine-directed intervention in experimental arthritis

    Författare :Karin Palmblad; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :pro-inflammatory cytokines; collagen-induced arthritis; CNI-1493; HMG-1;

    Sammanfattning : Rheumatoid arthritis (RA) is a common chronic autoimmune and inflammatory disease. Although the etiology of RA remains unknown, a general understanding of the pathogenesis is steadily increasing. The macrophage products tumor necrosis factor (TNF) and interleukin 1 (IL-1) are recognized as pivotal mediators in the arthritic process. LÄS MER

  3. 22. Effects of Th-1 and Th-2 Cytokines and Reactive Oxygen Species on Normal Human Bronchial Epithelial Cells

    Författare :Caroline Kampf; Benjamin Gaston; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; ytokines; desmosomes; focal adhesions; free radicals; hypochlorous acid; nitric oxide; normal human bronchial epithelial cells; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Sammanfattning : Epithelial damage and shedding of the epithelium are common observations in many airway diseases such as asthma, Sjögren’s syndrome, chronic obstructive pulmonary disease and cystic fibrosis. The ability of the cells to attach to each other and/or to the matrix seems to be altered. LÄS MER

  4. 23. Studies on the cytokine network in multiple sclerosis

    Författare :Pia Kivisäkk; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Multiple sclerosis (MS) is considered to be an inflammatory immune-mediated disease of the central nervous system (CNS), the aetiology of which remains enigmatic. Cytokines produced by infiltrating inflammatory cells and resident cells in the brain are proposed to play a major role in directing and regulating the immune response, as well as mediating tissue damage. LÄS MER

  5. 24. The contribution of epidermal apoptosis to the clinical outcome of Leishmania aethiopica induced cutaneous Leishmaniasis, and its laboratory diagnosis using low cost culture media

    Författare :Geremew Tasew Guma; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Cutaneous Leishmaniasis (CL) induced by Leishmania aethiopica has two clinical manifestations: ulcerating, self-healing CL and non-ulcerating, non-healing CL. The grossly disfiguring multiple nodules on the face and exterior surface of limbs during non-ulcerative CL are sometimes misdiagnosed as other skin infections. LÄS MER

  7. 25. Modulation of cellular and viral functions in Epstein-Barr virus infected cells

    Författare :Marta P Imreh; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The aim of the study was to investigate the interplay of cellular and viral genes in Epstein-Barr virus (EBV) infected cells. Two aspects of this interaction have been investigated. The first aspect is related to the expression of major histocompatibility complex (MHC) class I molecules in virus infected malignant cells. LÄS MER