Sökning: "tumor necrosis factor inhibition"

Visar resultat 16 - 20 av 32 avhandlingar innehållade orden tumor necrosis factor inhibition.

1. 16. Vascular Interactions in Innate Immunity and Immunothrombosis: : Models of Endothelial Protection

   Författare :Sofia Nordling; Peetra Magnusson; Paul Kubes; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endothelial cells; Thrombosis; Innate immunity; Immunothrombosis; Thromboinflammation; Immunologi; Immunology;

   Sammanfattning : The phenomenon known as immunothrombosis has garnered increased attention over the last few years. Much work has been done to characterize the cross talk between hemostasis and the innate immune system. LÄS MER

3. 17. Role of adhesion molecules and chemokines in TNF-alpha-induced leukocyte recruitment

   Författare :Xiao Wei Zhang; Kirurgi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; intravital microscopy; microcirculation; inflammation; adhesion; leukocyte; orthopaedics; traumatology; Kirurgi; ortopedi; traumatologi;

   Sammanfattning : Migration of leukocytes from the circulating blood into the extravascular tissue is a key component in inflammatory reactions. Leukocyte extravasation (rolling-activation-adhesion-transmigration) is strictly coordinated by adhesion molecules and chemokines expressed on cell surfaces and in tissues. LÄS MER

4. 18. Studies on vascular remodeling in acute coronary artery disease

   Författare :Fei Chen; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Atherosclerosis; unstable angina; matrix metalloproteinase; apoptosis; angiogenesis; remodeling;

   Sammanfattning : Atherosclerosis is an arterial disease, characterized by endothelial dysfunction, vascular inflammation, and lipid accumulation in the vessel wall. Unstable coronary syndroms may be initiated by rupture of the atherosclerotic plaque, which may be caused by activation of matrix metalloproteinases (MMPs), apoptosis and angiogenesis. LÄS MER

5. 19. Alpha1-Antitrypsin: New insights into the biological role in vitro and in vivo

   Författare :Izabela Nita; Enheten för kroniska inflammatoriska och degenerativa sjukdomar; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : Alpha1-Antitrypsin (AAT), an acute-phase glycoprotein produced predominantly in the liver by hepatocytes, but also by macrophages, pulmonary alveolar cells and intestinal epithelial cells, is a member of the SERPIN superfamily (SERine Protease INhibitors), and is one of the major inhibitors of neutrophil elastase in human plasma. Although AAT plays a critical role in regulating inflammation by inhibiting neutrophil serine proteases, recent studies suggest that AAT exhibits much broader anti-inflammatory activity. LÄS MER

7. 20. Modulating the activity of OGG1 using small molecules to target the oxidative DNA damage response in cancer and inflammation

   Författare :Bishoy M F Hanna; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The production of reactive oxygen species (ROS) is increased in several pathological conditions including cancer and inflammation. Multiple lines of evidence suggest that ROS are involved in signaling events that promote tumorigenesis and inflammatory responses. LÄS MER