Sökning: "splice acceptor"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden splice acceptor.

1. 1. The balance of splicing : A novel insight into the splicing regulation of high-risk HPV E6 and E7 oncogenes

   Författare :Johanna Jönsson; Naoko Kajitani; Stefan Schwartz; Ola Forslund; Francesca Aguilo; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; HPV; splice donor; splice acceptor; cis-element; trans-acting factor; pre-mRNA splicing; splicing regulation.; Medical Virology; Medicinsk virologi;

   Sammanfattning : HPV is associated with several cancers. The genome consists of a long control region, early (E1, E2, E4, E5, E6 and E7) and late (L1 and L2) genes. The E6 and E7 proteins prevent cells from entering apoptosis and regulate the cell cycle. A deregulated expression of these can result in malignant transformations. LÄS MER

3. 2. Characterisation of integrin splice variants and the interaction between integrins and the urokinase receptor

   Författare :Gunbjørg Svineng; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; integrin β1; alternative splicing; Alu element; urokinase receptor; Biokemi; Biochemistry; Biokemi; Medical Biochemistry; medicinsk biokemi;

   Sammanfattning : Integrins are a family of receptors involved in adhesion to extracellular matrix proteins and in cell-cell contacts. Each integrin consists of one a and one β subunit. Our main interest has been the β1 subunit and its splice variants. LÄS MER

4. 3. p53 inactivation by point mutations and splice site mutations in human and mouse tumors

   Författare :Kristinn P Magnússon; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :p53; Burkitt Iymphoma; apoptosis; alternative splicing; mutation; ascites;

   Sammanfattning : The p53 tumor suppressor gene is frequently mutated in human tumors. p53 induces cell cycle arrest and/or apoptosis in response to cellular stress, such as DNA damage, hypoxia and certain activated oncogenes like c-myc. The status of p53 in Burkitt's Iymphoma (BL) cell lines was investigated. The majority of BL lines expressed mutated p53 protein. LÄS MER

5. 4. Familial hypercholesterolemia in Sweden : genetic and metabolic studies

   Författare :Suzanne Lind; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Familial hypercholesterolemia; LDL receptor gene mutations; LDL cholesterol; bile acids; autosomal recessive hypercholesterolemia; growth hormone; LDL clearance.;

   Sammanfattning : Familial hypercholesterolemia (FH) is inherited as an autosomal codominant disease, usually caused by mutations in the LDL receptor (LDLR) gene. Heterozygous FH is a common disease with a prevalence of about 1/500 in most populations. Clinically, FH is characterized by elevated LDL cholesterol, tendon xanthomas and premature atherosclerosis. LÄS MER

7. 5. The Role of Polyadenylation in Human Papillomavirus Type 16 Late Gene Expression

   Författare :Daniel Öberg; Stefan Schwartz; Sheila Graham; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; HPV-16; polyadenylation; mRNA stability; codon usage; hnRNP H; DSE; splicing; negative element; RNA processing; Molekylärbiologi; Molecular biology; Molekylärbiologi;

   Sammanfattning : High-risk type human papillomaviruses (HPVs) are associated with cancer. HPVs are strictly epitheliotropic and infect basal cell layers, establishing a life cycle strongly linked to the differentiation stage of the infected cells. The viral capsid late genes, L2 and L1, are only expressed in terminally differentiated epithelium. LÄS MER