Sökning: "Sheila Graham"

Hittade 2 avhandlingar innehållade orden Sheila Graham.

  1. 1. Cellular and Viral Factors that Control Human Papillomavirus Type 16 Late Gene Expression

    Författare :Monika Somberg; Stefan Schwartz; Sheila Graham; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Virology; Virologi; Medical Virology; Medicinsk virologi;

    Sammanfattning : Human papillomavirus type 16 (HPV-16) is the major cause of cervical cancer. We speculate that inhibition of HPV-16 late gene expression is a prerequisite for establishment of persistence and progression to cervical cancer. LÄS MER

  3. 2. The Role of Polyadenylation in Human Papillomavirus Type 16 Late Gene Expression

    Författare :Daniel Öberg; Stefan Schwartz; Sheila Graham; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; HPV-16; polyadenylation; mRNA stability; codon usage; hnRNP H; DSE; splicing; negative element; RNA processing; Molekylärbiologi; Molecular biology; Molekylärbiologi;

    Sammanfattning : High-risk type human papillomaviruses (HPVs) are associated with cancer. HPVs are strictly epitheliotropic and infect basal cell layers, establishing a life cycle strongly linked to the differentiation stage of the infected cells. The viral capsid late genes, L2 and L1, are only expressed in terminally differentiated epithelium. LÄS MER