Sökning: "HPV-16"

Visar resultat 1 - 5 av 60 avhandlingar innehållade ordet HPV-16.

  1. 1. Regulation of Human Papillomavirus Type 16 Late L1 mRNA Splicing

    Författare :Xiaoze Li; Avdelningen för medicinsk mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HPV-16; cervical cancer; RNA processing; alternative splicing; splicing enhancer; splicing silencer; viral persistance; SR proteins; hnRNP proteins;

    Sammanfattning : Human papillomaviruses (HPVs) cause almost half of the human cancers that are attributable to viruses. HPV type 16 is the most carcinogenic type among the HPVs and is detected in 50% of all cervical cancers. HPV-16 infects epithelial cells and HPV-16 gene expression is tightly linked to the differentiation stage of the infected cells. LÄS MER

  3. 2. Regulation of RNA Processing in Human Papillomavirus Type 16

    Författare :Margaret Rush; Stefan Schwartz; Jörgen Kjems; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; RNA processing; human papillomavirus; HPV-16; alternative splicing; polyadenylation; exonic splicing enhancer; 3 UTR; upstream polyadenylation element; SR proteins; Molekylärbiologi; Molecular biology; Molekylärbiologi;

    Sammanfattning : Human papillomavirus type 16 (HPV-16) is the major cause of cervical cancer. HPV-16 gene expression is tightly linked to the differentiation programme of the infected epithelium. Expression of the late genes, L1 and L2, encoding the capsid proteins, is delayed until the more terminally differentiated cells. LÄS MER

  4. 3. Posttranscriptional Regulation of Human Papillomavirus Type 16 Late mRNAs

    Författare :Brian Collier; Carl Baker; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; HPV 16; Negative Element; Translation; mRNA stability; Codon Usage; RNA binding proteins; Biokemi; Biochemistry; Biokemi; Medical Virology; medicinsk virologi;

    Sammanfattning : The lifecycle of the human papillomavirus (HPV) is strictly linked to the programmed differentiation of the host cell it infects. Production of late proteins, which are used for the production of the major and minor capsid proteins, is only seen upon terminal differentiation of the epithelium. LÄS MER

  5. 4. Control of human papillomavirus type 1 late mRNA stability and translation by an AU-rich RNA element

    Författare :Marcus Sokolowski; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; HPV-1; HPV-16; late genes; 3´ UTR; L1; L2; c-fos; AU rich element; HuR; hnRNP C1 C2; mRNA stability; translation; Biokemi; Biochemistry; Biokemi; Medical Virology; medicinsk virologi;

    Sammanfattning : Human Papillomaviruses (HPVs) infect the epithelial tissues in humans and infection with certain high-risk types is associated with cancer. The expressionof the HPV late capsid genes is dependent on cell differentiation. This may be one reason for the lack of HPV replication in vitro. LÄS MER

  7. 5. The Role of Polyadenylation in Human Papillomavirus Type 16 Late Gene Expression

    Författare :Daniel Öberg; Stefan Schwartz; Sheila Graham; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; HPV-16; polyadenylation; mRNA stability; codon usage; hnRNP H; DSE; splicing; negative element; RNA processing; Molekylärbiologi; Molecular biology; Molekylärbiologi;

    Sammanfattning : High-risk type human papillomaviruses (HPVs) are associated with cancer. HPVs are strictly epitheliotropic and infect basal cell layers, establishing a life cycle strongly linked to the differentiation stage of the infected cells. The viral capsid late genes, L2 and L1, are only expressed in terminally differentiated epithelium. LÄS MER