Sökning: "repeated DNA"

Visar resultat 21 - 25 av 91 avhandlingar innehållade orden repeated DNA.

  1. 21. The attenuation of the P53 response to DNA damage in rodent liver preneoplastic enzyme-altered foci

    Författare :Niklas Finnberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Enzyme-altered foci; p53; ATM; diethylnitrosamine; phenobarbital; liver; gene dosage;

    Sammanfattning : In connection with life-time bioassays in rodents, the liver is one of the organs most frequently affected. During the carcinogenic process, single preneoplastic hepatocytes develop into hepatocellular adenoma or carcinoma (HCC). LÄS MER

  3. 22. Measurement of primary DNA damage in individual cells from humans and mice using the alkaline single cell gel electrophoresis assay

    Författare :Hamid Vaghef; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; arbets- och miljömedicin; Occupational and Environmental Medicine;

    Sammanfattning : Primary DNA damage is considered to be an important step in the development of tumours and itmay also serve as a biomarker of genotoxic stress. Measurement of DNA strand breaks in peripherallymphocytes can yield useful information about the suitability of these cells for biomonitoring purposesand subsequently risk assessment. LÄS MER

  4. 23. Disentangling the Reticulate History of Polyploids in Silene (Caryophyllaceae)

    Författare :Magnus Popp; Bengt Oxelman; Magnus Lidén; Jeff J. Doyle; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biology; Silene; Sileneae; polyploidy; low copy nuclear DNA; RNA polymerase; RPA2; RPB2; RPD2; internal transcribed spacer; rps16; psbE-petL; concerted evolution; reticulate evolution; lineage sorting; Biologi; Biology; Biologi;

    Sammanfattning : DNA sequences from the rps16 intron and the psbE-petL spacer from the chloroplast genome, the ribosomal nuclear ITS region, and introns from the low copy nuclear genes RPA2, RPB2, RPD2a and RPD2b, are in different combinations used to infer phylogenetic relationships in Sileneae (Caryophyllaceae). Used in concert, the biparentally inherited nuclear regions are useful to distinguish between paralogy due to allopolyploidy and single gene duplications, respectively, because the latter are not expected to give rise to repeated phylogenetic patterns in potentially unlinked sequence regions. LÄS MER

  5. 24. Solving repeat problems in shotgun sequencing

    Författare :Erik Arner; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Shotgun sequencing; repeated DNA; genomics; whole genome shotgun; hierarchical shotgun; mate pairs; DNP; bioinformatics;

    Sammanfattning : Shotgun sequencing is the most powerful strategy for large scale sequencing. Two main approaches exist: clone-by-clone and whole genome shotgun (WGS). In the clone-by-clone strategy, overlapping clones are amplified and then sheared in a random fashion. LÄS MER

  7. 25. Mitotic failure and genome stability in benign, premalignant and malignant human tissues

    Författare :Rüdiger G Steinbeck; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :aneuploidy; CDF; clonal selection; DNA content; image microphotometry; interphase; microsection; nondisjunction; unbalanced telophase;

    Sammanfattning : Mitotic failure may occur throughout the human lifespan. Individual nuclear mistakes will escape detection within the mass of somatic cells. The probability of nondetection increases with progression in development. LÄS MER