Sökning: "Shotgun sequencing"
Visar resultat 1 - 5 av 24 avhandlingar innehållade orden Shotgun sequencing.
1. Software Tools and Algorithms for Shotgun Sequence Assembly
Sammanfattning : During the last ten years, a genomics revolution has changed the ways biological research is carried out. The draft sequence of the human genome is available, as well as the sequence of 84 other completed genomes. LÄS MER
2. Solving repeat problems in shotgun sequencing
Sammanfattning : Shotgun sequencing is the most powerful strategy for large scale sequencing. Two main approaches exist: clone-by-clone and whole genome shotgun (WGS). In the clone-by-clone strategy, overlapping clones are amplified and then sheared in a random fashion. LÄS MER
3. Computational methods for analysis of fragmented sequence data
Sammanfattning : Recent developments in genomic and proteomic sequencing technologies have revolutionized research in life sciences, providing new opportunities for the study of biological systems. However, modern sequence data sets are large, diverse, and heavily fragmented, which presents new challenges for their analysis and interpretation. LÄS MER
4. Thermodynamics of Protein Folding and Design
Sammanfattning : The protein folding and protein design problems are addressed, using coarse-grained models with only two types of amino acids, hydrophobic and hydrophilic. In addition to hydrophobicity forces, the models contain sequence-independent local interactions which are found to strongly influence the thermodynamics of these models. LÄS MER
5. Microbial biofilm communities associated with degradation of sprayed concrete in subsea tunnels
Sammanfattning : Deterioration of concrete leads to reduced structural strength implying high societal challenge with huge economic impact. In the Oslofjord subsea tunnel, complex microbial biofilm activity together with abiotic attack from saline groundwater are responsible for concrete matrix degradation and steel fiber corrosion. LÄS MER