Sökning: "Enzyme-altered foci"

Hittade 2 avhandlingar innehållade orden Enzyme-altered foci.

  1. 1. The attenuation of the P53 response to DNA damage in rodent liver preneoplastic enzyme-altered foci

    Författare :Niklas Finnberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Enzyme-altered foci; p53; ATM; diethylnitrosamine; phenobarbital; liver; gene dosage;

    Sammanfattning : In connection with life-time bioassays in rodents, the liver is one of the organs most frequently affected. During the carcinogenic process, single preneoplastic hepatocytes develop into hepatocellular adenoma or carcinoma (HCC). LÄS MER

  3. 2. Regulation of p53 and susceptibility to cell death in chemically-induced preneoplastic hepatocytes

    Författare :Ilona Silins; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Induction of preneoplastic lesions, termed enzyme-altered foci (EAF), is considered to be an early step in the development of liver cancer. In view of the relatively homogenous properties of the majority of EAF, these lesions are suggested to arise as an adaptive response to toxic stress. LÄS MER