Sökning: "diethylnitrosamine"
Hittade 4 avhandlingar innehållade ordet diethylnitrosamine.
1. The attenuation of the P53 response to DNA damage in rodent liver preneoplastic enzyme-altered foci
Sammanfattning : In connection with life-time bioassays in rodents, the liver is one of the organs most frequently affected. During the carcinogenic process, single preneoplastic hepatocytes develop into hepatocellular adenoma or carcinoma (HCC). LÄS MER
2. Thioredoxin reductase and selenium in carcinogenesis and multidrug resistance
Sammanfattning : The thioredoxin system, comprising thioredoxin, thioredoxin reductase (TrxR) and NADPH, is a redox system of great importance in the defence against oxidative stress and is involved in the regulation of several cellular processes, such as apoptosis and cell proliferation. In addition, TrxR is a selenoenzyme and is a key enzyme in selenium metabolism. LÄS MER
3. Hormonal regulation of sex differentiated liver carcinogenesis in the rat
Sammanfattning : Endocrine factors influence cancer development in a variety of reproductive and non-reproductive tissues and organs. The incidence of liver cancer is higher in men than in women and long-term administration of androgens and estrogens has been reported to increase the risk for liver cancer formation, supporting the importance of hormonal factors in the etiology of this tumor. LÄS MER
4. Regulation of p53 and susceptibility to cell death in chemically-induced preneoplastic hepatocytes
Sammanfattning : Induction of preneoplastic lesions, termed enzyme-altered foci (EAF), is considered to be an early step in the development of liver cancer. In view of the relatively homogenous properties of the majority of EAF, these lesions are suggested to arise as an adaptive response to toxic stress. LÄS MER
