Sökning: "gene dosage"

Visar resultat 1 - 5 av 65 avhandlingar innehållade orden gene dosage.

  1. 1. Avian Genome Evolution - Gene Expression, Gene Divergence and Sexual Dimorphism

    Författare :Sara Naurin; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; sex chromosome; avian genome evolution; gene expression; sexual dimorphism; Z chromosome;

    Sammanfattning : This study has focused on: (i) differences in how males and females use the genes in the genome, (ii) how sex chromosomes evolve and (iii) how the evolutionary rate of genes are affected by the chromosome on which they are located on and the gene expression level they experience. A large-scale microarray was developed for the zebra finch, Taeniopygia guttata and techniques were developed so that this microarray could also be used for wild passerine birds. LÄS MER

  3. 2. Adenovirus-mediated Gene Therapy of Prostate Cancer

    Författare :Angelika Danielsson; Mangus Essand; Thomas H. Tötterman; Gunnel Hallden; Uppsala universitet; []
    Nyckelord :adenovirus; adenoviral vector; oncolytic virus; gene therapy; prostate cancer; PEGylation; HDAC inhibitor; whole blood model; whole blood neutralization assay; MEDICINE; MEDICIN; Klinisk immunologi; Clinical Immunology; Molekylär genetik; Molecular Genetics;

    Sammanfattning : Adenovirus-mediated gene therapy is a potential complement to standard cancer treatments. Advantages are that vectors can be used to target tumors and that replicating viruses lead to increased therapeutic dosage. LÄS MER

  4. 3. Genomic adaptation and gene-dosage regulation of Drosophila melanogaster cells, and long-read software developments

    Författare :Jacob Lewerentz; Per Stenberg; Jan Larsson; Bergman Casey; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Drosophila; cell line; long read; Nanopore; Pacbio; Illumina; cancer; genome evolution; dosage compensation; structural variant; software; bioinformatics;

    Sammanfattning : Cells are the vehicles that allows genetic code to proliferate in the world, taking on various forms – as illustrated by the tree of life. The cell features are determined by the manufacturing of proteins, a process that has its blueprints encoded as genes in the genome. LÄS MER

  5. 4. The Evolution of Sex Chromosomes and Dosage Compensation in Structurally Dynamic Butterfly Genomes

    Författare :Lars Höök; Niclas Backström; Elina Immonen; Beatriz Vicoso; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Sex chromosome evolution; Dosage compensation; Sex-biased gene expression; Faster-Z; Lepidoptera; Biology with specialization in Evolutionary Genetics; Biologi med inriktning mot evolutionär genetik;

    Sammanfattning : Dimorphic sex chromosomes have evolved independently throughout evolution from initially homologous autosomes. Recombination suppression between the sex chromosomes causes one sex chromosome to degenerate, which will influence evolution of sex-linked genes. LÄS MER

  7. 5. Chromosome-wide gene regulatory mechanisms in Drosophila melanogaster

    Författare :Anna-Mia Johansson; Jan Larsson; Kristen M. Johansen; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chromatin structure; Drosophila; POF; disage compensation; gene expression; MSL; heterochromatin; Genetics; Genetik; genetik; Genetics;

    Sammanfattning : In Drosophila there are two different chromosome-wide targeting systems, the dosage compensation system that equalizes the transcriptional output from X-linked genes between males and females, and the regulation of the 4th chromosome mediated by the POF protein.   The best studied of these two mechanisms is the dosage compensation system. LÄS MER