Sökning: "hierarchical shotgun"

Hittade 2 avhandlingar innehållade orden hierarchical shotgun.

1. 1. Solving repeat problems in shotgun sequencing

   Författare :Erik Arner; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Shotgun sequencing; repeated DNA; genomics; whole genome shotgun; hierarchical shotgun; mate pairs; DNP; bioinformatics;

   Sammanfattning : Shotgun sequencing is the most powerful strategy for large scale sequencing. Two main approaches exist: clone-by-clone and whole genome shotgun (WGS). In the clone-by-clone strategy, overlapping clones are amplified and then sheared in a random fashion. LÄS MER

3. 2. Machine Learning methods in shotgun proteomics

   Författare :Patrick Truong; Lukas Käll; Peter Nilsson; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mass spectrometry protein summarization Bayesian hierarchical modelling label-free quantification data-independent acquisition mass spectrometry; benchmark mathematical methods; transformers; computational proteomics; proteomics; bioinformatics; bert; ms2 intensity; probabilistic modelling; Biotechnology; Bioteknologi;

   Sammanfattning : As high-throughput biology experiments generate increasing amounts of data, the field is naturally turning to data-driven methods for the analysis and extraction of novel insights. These insights into biological systems are crucial for understanding disease progression, drug targets, treatment development, and diagnostics methods, ultimately leading to improving human health and well-being, as well as, deeper insight into cellular biology. LÄS MER