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1. 6. Novel Interventions in Cardiac Arrest : Targeted Temperature Management, Methylene Blue, S-PBN, Amiodarone, Milrinone and Esmolol,  Endothelin and Nitric Oxide In Porcine Resuscitation Models

   Författare :Frank Zoerner; Fredrik Lennmyr; Cécile Martijn; Lars Wiklund; Sven Erik Gisvold; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; restoration of spontaneous circulation; ROSC; cardiopulmonary resuscitation; CPR; cardiac arrest; methylene blue; MB; S-PBN; mild therapeutic hypothermia; MTH; targeted temperature management; TTM; endothelin; ET-1; ECE-1; ETAR; ETBR; nitric oxide; NO; nitric oxide synthase; NOS; eNOS; iNOS; nNOS; porcine; amiodarone; hypovolemia; milrinone; vasopressin; esmolol; epinephrine; Anestesiologi och intensivvård; Anaesthesiology and Intensive Care; Medical Cell Biology; Medicinsk cellbiologi; Cardiology; Kardiologi;

   Sammanfattning : It is a major clinical problem that survival rates after out-of-hospital cardiac arrest have not markedly improved during the last decades, despite extensive research and the introduction of new interventions. However, recent studies have demonstrated promising treatments such as targeted temperature management (TTM) and methylene blue (MB). LÄS MER

3. 7. Inhaled Nitric Oxide Therapy : Non-response and Rebound Response

   Författare :Luni Chen; Eddie Weitzberg; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anaesthesiology and intensive care; nitric oxide inhalation; rebound response; non-response; endothelin-1; COX inhibitor; prostaglandin; ARDS; endotoxin; oleic acid; Anestesiologi och intensivvård; Anaesthetics and intensive care; Anestesiologi och intensivvård; Clinical Physiology; klinisk fysiologi;

   Sammanfattning : Therapeutic inhaled nitric oxide (INO) has proved beneficial in patients with pulmonary hypertension. However, around 30-40% of the patients are non-responders to this therapy, and a life-threatening rebound response may occur during attempts to withdraw INO. LÄS MER

4. 8. Solar Forcing of Nitric Oxide in the Upper Atmosphere

   Författare :Koen Hendrickx; Linda Megner; Jörg Gumbel; Bernd Funke; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; nitric oxide; NO; mesosphere; lower thermosphere; MLT; energetic particle precipitation; EPP; medium energy electrons; MEE; SOFIE; SNOE; WACCM; POES; atmosfärvetenskap och oceanografi; Atmospheric Sciences and Oceanography;

   Sammanfattning : The forcing of the Sun on Earth's atmosphere manifests itself via solar radiation and energetic particle precipitation (EPP), which variations are most noticeable in the upper regions of the atmosphere. A key species in the lower thermosphere, which is influenced by solar forcing, is nitric oxide (NO). LÄS MER

5. 9. Nitric Oxide Exchange in Central and Peripheral Airways : Determinants in Health and Respiratory Disease

   Författare :Andrei Malinovschi; Christer Janson; Kjell Alving; Lena Holm; Elisabeth Bel; Uppsala universitet; []
   Nyckelord :exhaled nitric oxide; alveolar NO; bronchial NO flux; extended NO analysis; asthma; smoking; snus; IgE-sensitization; pharyngo-oral tract; nitrate; nitrite; pulmonary hypertension;

   Sammanfattning : Background: Exhaled nitric oxide (NO) is a marker of eosinophilic steroid-sensitive inflammation in the airways of patients with respiratory disease. Moreover, information about the localization of inflammation in the respiratory tree is obtained by estimates of bronchial and alveolar contributions to exhaled NO. LÄS MER

7. 10. Endogenous Nitric Oxide Production and Pulmonary Blood Flow : during different experimental lung conditions

   Författare :Manja Nilsson; Filip Fredén; Kristina Hambraeus-Jonzon; Göran Hedenstierna; Eddie Weitzberg; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Nitric oxide; pulmonary blood flow; endotoxin; nitric oxide inhalation; endothelin; hypercapnia; acidosis; lavage-induced lung injury; Anaesthetics and intensive care; Anestesiologi och intensivvård; Anestesiologi och intensivvård; Anaesthesiology and Intensive Care;

   Sammanfattning : Nitric oxide (NO) is an important regulator of pulmonary blood flow and attenuates hypoxic pulmonary vasoconstriction (HPV). Nitric oxide is synthesized enzymatically in a number of tissues, including the lungs, and can also be generated from reduction of nitrite during hypoxia and acidosis. LÄS MER