Sökning: "ET-1"

Visar resultat 1 - 5 av 55 avhandlingar innehållade ordet ET-1.

  1. 1. Novel Interventions in Cardiac Arrest Targeted Temperature Management, Methylene Blue, S-PBN, Amiodarone, Milrinone and Esmolol,  Endothelin and Nitric Oxide In Porcine Resuscitation Models

    Detta är en avhandling från Uppsala : Uppsala universitet

    Författare :Frank Zoerner; Uppsala universitet.; [2015]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; restoration of spontaneous circulation; ROSC; cardiopulmonary resuscitation; CPR; cardiac arrest; methylene blue; MB; S-PBN; mild therapeutic hypothermia; MTH; targeted temperature management; TTM; endothelin; ET-1; ECE-1; ETAR; ETBR; nitric oxide; NO; nitric oxide synthase; NOS; eNOS; iNOS; nNOS; porcine; amiodarone; hypovolemia; milrinone; vasopressin; esmolol; epinephrine; Anaesthesiology and Intensive Care; Anestesiologi och intensivvård; Medical Cell Biology; Medicinsk cellbiologi; Kardiologi; Cardiology;

    Sammanfattning : It is a major clinical problem that survival rates after out-of-hospital cardiac arrest have not markedly improved during the last decades, despite extensive research and the introduction of new interventions. However, recent studies have demonstrated promising treatments such as targeted temperature management (TTM) and methylene blue (MB). LÄS MER

  2. 2. Cardiovascular and metabolic effects of endothelins in man : an experimental and clinical study

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Clinical Sciences

    Författare :Astrid Ottosson-Seeberger; Karolinska Institutet.; Karolinska Institutet.; [1998]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; endothelin-1; big ET-1; C-terminal big ET-1 22-3 8 fragment; hemodynamic; blood flow; fractional extraction; conversion; plasma half-life; end-stage renal failure; ischemic heart disease; hemodialysis; high-flux membrane; glucose uptake; insulin sensitivity;

    Sammanfattning : Increased plasma concentrations of endothelin-1 (ET-1) and of its propeptide big endothelin-1 have been reported in diseases associated with endothelial dysfunction, cardiovascular remodelling and insulin resistance. In this thesis, we studied the hemodynamic effects of big ET-1 in healthy humans focusing on the mechanisms of the effects (study I-IV). LÄS MER

  3. 3. Unusual vascular responses in the umbilical artery, mediated by endothelin-like receptors

    Detta är en avhandling från Inscan, Copenhagen, DENMARK

    Författare :Maria Laursen; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; reproduction; sexuality; Obstetrik; gynekologi; andrologi; sexualitet; andrology; gynaecology; Obstetrics; Medicin människa och djur ; Medicine human and vertebrates ; unusual vascular responses; endothelin-like receptors; human umbilical artery; reproduktion;

    Sammanfattning : In this present study the population of endothelin-like receptors in the human umbilical artery was examined in vitro in different parts of the umbilical cord. Immunohistochemistry revealed ETB receptors in the endothelium and an uneven distribution of ETA receptors in the smooth muscle of the arterial wall, when comparing different parts of the umbilical artery. LÄS MER

  4. 4. The importance of endothelin-1 for vascular function in patients with atherosclerosis and healthy controls

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Medicine

    Författare :Felix Böhm; Karolinska Institutet.; Karolinska Institutet.; [2002]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acetylcholine; atherosclerosis; blood flow; circulation; coronary disease; endothelin; endothelium; kidney; liver; nitric oxide; patients; receptors; vasoconstriction.;

    Sammanfattning : Background: Atherosclerosis is associated with endothelial dysfunction, which is an early sign with prognostic implications in patients with coronary artery disease. Atherosclerosis is also associated with enhanced expression of the vasoconstrictor peptide endothelin-1 (ET-1). LÄS MER

  5. 5. Endothelium-derived Vasoactive Factors and Leukocyte-derived Inflammatory Mediators. Studies in subjects with or at risk for vascular disease

    Detta är en avhandling från Wallenberg Lab. Plan 2,University Hospital , Malmö, S-20502, Malmö, SWEDEN. After 1999-07-10 new address, P.O. Box 1042, Benghazi, Libya

    Författare :Anwaar M Ibrahim; [1999]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostacyclin.; Postmenopausal hormone replacement therapy; Nitric oxide; Endothelin; Diabetes mellitus; Cytokines; Cholesterol; Atherosclerosis; Cerebral ischemia; Cardiovascular system; Kardiovaskulära systemet;

    Sammanfattning : This study was undertaken to evaluate relationships between endothelial function (assessed as mediators of endothelium-derived vasoactive factors such as nitric oxide [NO], prostacyclin [PGI2] and endothelin [ET-1] ), and risk factors for atherosclerosis, as well as to study possible relationships between endothelial function and leukocyte activation (indicated by measurements of leukocyte-derived inflammatory mediators) in subjects with or at risk for atherosclerosis. In subjects with asymptomatic atherosclerosis we found inverse relationships between cyclic guanosine monophosphate (cGMP) in platelets (mediator of NO activity) and both serum total cholesterol and plasma ET-1 suggesting that NO-mediated vasodilation may be impaired in hypercholesterolemia and that maintenance of vascular tone is achieved by a balance between NO and ET-1. LÄS MER