Sökning: "rebound response"
Visar resultat 1 - 5 av 23 avhandlingar innehållade orden rebound response.
1. Inhaled Nitric Oxide Therapy : Non-response and Rebound Response
Sammanfattning : Therapeutic inhaled nitric oxide (INO) has proved beneficial in patients with pulmonary hypertension. However, around 30-40% of the patients are non-responders to this therapy, and a life-threatening rebound response may occur during attempts to withdraw INO. LÄS MER
2. Modelling of tolerance and rebound in normal and diseased rats
Sammanfattning : The development of rebound and tolerance is an important consideration when optimizing medical therapy, both with respect to drug dosing and adverse effects. By using quantitative approaches to study these processes, potential risks can be minimized. LÄS MER
3. Pharmacokinetic-Pharmacodynamic Modelling of Anticancer Drugs : Haematological Toxicity and Tumour Response in Hollow Fibres
Sammanfattning : Established quantitative relationships between dose, plasma concentrations and response [pharmacokinetic-pharmacodynamic (PKPD) models] have a high potential in improving therapeutic indices of anticancer drug therapy and in increasing drug development efficiency. PKPD modelling is a helpful tool for characterising and understanding schedule dependence. LÄS MER
4. Immune response during hepatitis B virus infection and reconstitution of HBV-specific immunity using T cells redirected against HBV
Sammanfattning : Hepatitis B is one of the most prevalent viral diseases worldwide and is a major public health concern, particularly in Asia. Of the 350 million people suffering from chronic hepatitis B virus (HBV) infection worldwide, approximately 75% are found in Asia. LÄS MER
5. Effects of Seat and Seat-Belt Design on Car Occupant Response in Frontal and Rear Impacts A Study Combining Mechanical and Mathematical Modelling
Sammanfattning : The objective of the present work is to determine the potential injury-reducing benefits to car occupants in accidents of seat and seat-belt design. The main problems addressed are the risk of injury to head, neck, and upper torso in frontal impacts, and the risk of minor neck-injuries - whiplash-injuries - in rear-end collisions. LÄS MER