Sökning: "mcts"

Visar resultat 1 - 5 av 11 avhandlingar innehållade ordet mcts.

  1. 1. Acoustic manipulation for cell and spheroid cellomics

    Författare :Karl Olofsson; Martin Viklund; Maria Tenje; KTH; []
    Nyckelord :Biological and Biomedical Physics; Biologisk och biomedicinsk fysik;

    Sammanfattning : Ultrasonic standing wave (USW) particle manipulation has during the last two decades matured into a valuable tool to combine with microfluidics. Acoustophoresis, migration through sound, is the result of the acoustic radiation force acting on particles suspended in an acoustic field. LÄS MER

  3. 2. High-throughput screening using multicellular tumor spheroids to reveal and exploit tumor-specific vulnerabilities

    Författare :Wojciech Senkowski; Mårten Fryknäs; Rolf Larsson; Peter Nygren; Mats Gustafsson; Krister Wennerberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; spheroids; high-throughput screening; nitazoxanide; OXPHOS; gene expression profiling; statins; drug repositioning; 3D cell culture; quiescent cells; Medical Science; Medicinsk vetenskap;

    Sammanfattning : High-throughput drug screening (HTS) in live cells is often a vital part of the preclinical anticancer drug discovery process. So far, two-dimensional (2D) monolayer cell cultures have been the most prevalent model in HTS endeavors. However, 2D cell cultures often fail to recapitulate the complex microenvironments of in vivo tumors. LÄS MER

  4. 3. Construction, expression and evaluation of anti-keratin 8 single-chain antibody fragments

    Författare :Rozbeh Jafari; Birgitta Sundström; Jörgen Carlsson; Karlstads universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Single-chain antibody fragments; keratin 8; site-directed mutagenesis; heterologous expression; P. pastoris; design of experiments; multicellular tumor spheroids; immunotargeting; Biomedical Sciences; Biomedicinsk vetenskap;

    Sammanfattning : Antibodies are glycoproteins specifically binding to a variety of antigens and today extensively used in prevention, diagnosis and treatment of diseases. Carcinomas originate from epithelial tissues and are the most common forms of human malignancies. In the necrotic areas of carcinomas significant amounts of keratins (K) are found extracellularly. LÄS MER

  5. 4. Development of Monte Carlo track structure simulations for protons and carbon ions in water

    Författare :Thiansin Liamsuwan; Hooshang Nikjoo; Shuzo Uehara; David Liljequist; Michael Dingfelder; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Radiation track structure; Monte Carlo simulations; interaction cross sections; classical trajectory Monte Carlo CTMC method; microdosimetry; ion beams; Medical Radiation Physics; medicinsk strålningsfysik;

    Sammanfattning : The goal of radiation therapy is to eradicate tumour cells while minimising radiation dose to healthy tissues. Ions including protons and carbon ions have gained increasing interest for cancer treatment. LÄS MER

  7. 5. Utilizing Biopolymers in 3D Tumor Modeling and Tumor Diagnosis

    Författare :Negar Abbasi Aval; Torbjörn Pettersson; Aman Russom; Maria Tenje; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; 3D tumor modeling; Spheroids; Cellulose Nano Fibrils; Layer by Layer; Extracellular matrix; Circulating Tumor Capturing; Pancreatic ductal adenocarcinoma PDAC ; 3D-tumörmodellering; Sfärer; Cellulosa; Lager-på-lager; Extracellulärmatris; Infångning av cirkulerande tumörceller; Mänskliga Duktala Adenocarcinom-Hepatocyter; Fiber- och polymervetenskap; Fibre and Polymer Science;

    Sammanfattning : Cancer represents a significant global public health challenge and ranks as the second mostcommon cause of death in the United States. The onset of cancer entails an initial phasewhere cells lose their polarity and disconnect from the normal basement membrane, allowingthem to form distinct three-dimensional (3D) configurations that interact with adjacent cellsand the surrounding microenvironment. LÄS MER