Sökning: "Single-chain antibody fragments"

Visar resultat 1 - 5 av 12 avhandlingar innehållade orden Single-chain antibody fragments.

  1. 1. Construction, expression and evaluation of anti-keratin 8 single-chain antibody fragments

    Författare :Rozbeh Jafari; Birgitta Sundström; Jörgen Carlsson; Karlstads universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Single-chain antibody fragments; keratin 8; site-directed mutagenesis; heterologous expression; P. pastoris; design of experiments; multicellular tumor spheroids; immunotargeting; Biomedical Sciences; Biomedicinsk vetenskap;

    Sammanfattning : Antibodies are glycoproteins specifically binding to a variety of antigens and today extensively used in prevention, diagnosis and treatment of diseases. Carcinomas originate from epithelial tissues and are the most common forms of human malignancies. In the necrotic areas of carcinomas significant amounts of keratins (K) are found extracellularly. LÄS MER

  3. 2. Calcium-dependent Affinity Domains for the Purification of Antibodies and Antibody Fragments

    Författare :Julia Scheffel; Sophia Hober; Alois Jungbauer; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Antibodies; Antibody fragments; Biomanufacturing; Protein purification; Protein engineering; Protein A; ZCa; Calcium; Mild elution; Bioteknologi; Biotechnology;

    Sammanfattning : Antibodies are essential proteins in both our bodies and biotechnological research, and hold outstanding therapeutic value. The market for antibody-based therapeutics has grown exponentially during the last decades, owing to several advantages over small molecule drugs, such as fewer undesirable side effects associated with a higher target specificity. LÄS MER

  4. 3. Lactobacilli expressing antibody fragments against pathogens

    Författare :Anna Hultberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Adherence to mucosal surfaces has been shown to be of great importance in the pathogenesis of various infections in the gastro-intestinal tract. Live recombinant bacteria can be used to deliver active or passive immunity at the mucosal surface, which is the site of entry for the majority of the pathogens. LÄS MER

  5. 4. Functionalization of spider silk with affinity and bioactive domains via genetic engineering for in vitro disease diagnosis and tissue engineering

    Författare :Naresh Thatikonda; My Hedhammar; Hanna Dams Kozlowska; KTH; []
    Nyckelord :affinity domains; artificial ECM; basic fibroblast growth factor; functionalization; mammalian cell culture; micro-and nano arrays; partial spider silk; single chain variable fragments; Bioteknologi; Biotechnology;

    Sammanfattning : In the recent past, spider silk has drawn significant attention from researchers mainly due to its distinguished mechanical strength, elasticity, biocompatibility and biodegradability. Technological advancements in genetic engineering have resulted in methods for creation of partial spider silk proteins. LÄS MER

  7. 5. Targeting molecules for diagnostics of Head and Neck squamous cell carcinoma

    Författare :Anna-Karin Haylock; Marika Nestor; Göran Laurell; Matti Anniko; Katrine Riklund; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HNSCC; CD44v6; radio-immunodiagnosis; immuno-PET; tumor targeting; antibodies; antibody fragments; Oto-Rhino-Laryngology; Oto-rhino-laryngologi;

    Sammanfattning : To personalize treatment for cancer, correct staging of the primary tumor, nodal disease and metastatic disease is of essence. By targeting tumor specific receptors with radiolabeled antibodies, specificity and accuracy of imaging may be improved. LÄS MER