Sökning: "Pancreatic ductal adenocarcinoma PDAC"
Visar resultat 1 - 5 av 26 avhandlingar innehållade orden Pancreatic ductal adenocarcinoma PDAC.
1. Repurposing digitoxin in the treatment of pancreatic ductal adenocarcinoma : genotypic and phenotypic features as biomarkers for digitoxin sensitivity in vitro
Sammanfattning : The incidence of pancreatic ductal adenocarcinoma (PDAC) is increasing worldwide. The dismal prognosis and lack of effective treatments urges for increased research efforts in developing new treatment regimens. Since the development of new cancer treatments are expensive and time consuming, repurposing drugs is preferable when possible. LÄS MER
2. In search of early biomarkers in pancreatic ductal adenocarcinoma using multi-omics and bioinformatics
Sammanfattning : Background: Pancreatic ductal adenocarcinoma (PDAC) is a very aggressive malignancy with a 5-year survival of 10 %. Surgery is the only curative treatment. Unfortunately, few patients are eligible for surgery due to late detection. Thus, we need ways to detect the disease at an earlier stage and for that good screening biomarkers could be used. LÄS MER
3. The identification and functional evaluation of novel cancer-associated fibroblast subtypes and matrisome proteins in pancreatic cancer
Sammanfattning : Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy characterized by an extensive desmoplastic stroma. The stroma is the site of intricate communication between malignant cells and their surrounding environment. LÄS MER
4. Characterizing the pancreatic "isletome" : 3D optical imaging to study diabetes
Sammanfattning : The pancreas is a specialised multipurpose organ, that can be separated into two major compartments: endocrine and exocrine. The exocrine part makes up the majority of the organ volume and functions to secrete digestive enzymes into the small intestine. LÄS MER
5. Pancreatic ductal adenocarcinoma : computed tomography for diagnosis, local staging and prediction of postoperative complications
Sammanfattning : Pancreatic ductal adenocarcinoma (PDAC) is a disease with a dismal prognosis, being the 4th leading cause of cancer deaths in Sweden and worldwide. The only potentially curative therapy is surgery. Unfortunately, by the time of diagnosis only 20% of patients have a resectable tumor and the overall 5-year survival rate does not exceed 5%. LÄS MER