Sökning: "spheroids"
Visar resultat 1 - 5 av 39 avhandlingar innehållade ordet spheroids.
1. High-throughput screening using multicellular tumor spheroids to reveal and exploit tumor-specific vulnerabilities
Sammanfattning : High-throughput drug screening (HTS) in live cells is often a vital part of the preclinical anticancer drug discovery process. So far, two-dimensional (2D) monolayer cell cultures have been the most prevalent model in HTS endeavors. However, 2D cell cultures often fail to recapitulate the complex microenvironments of in vivo tumors. LÄS MER
2. New preclinical strategies for characterization and development of anticancer drugs
Sammanfattning : Increased understanding of the molecular mechanisms underlying cancer development has shifted drug discovery towards target driven drug development the last decades, but the development of effective cancer drugs has been hampered by the lack of predictive preclinical models. 3-D cultures, considered to more accurately reflect solid tumors in vivo, have been proposed as one way to increase the predictability of clinical efficacy in cancer drug discovery and development. LÄS MER
3. Multicellular Tumour Spheroids in a Translational PET Imaging Strategy
Sammanfattning : Positron Emission Tomography (PET) has gained an important roll in clinical for diagnosis, staging and prognosis of a range of cancer types. Utilization of PET for monitoring and evaluation of cancer treatment is an attractive but almost new concept. The proper choice of PET-tracer as a biomarker for treatment follow-up is crucial. LÄS MER
4. Tumour models in vitro : a study of proliferation and growth in cellular spheroids
Sammanfattning : .... LÄS MER
5. Tumour models in vitro : on the use of multicellular spheroids in studies of antitumour drugs
Sammanfattning : .... LÄS MER
