Sökning: "Precursor of Dopamine"

Visar resultat 1 - 5 av 33 avhandlingar innehållade orden Precursor of Dopamine.

  1. 1. On dopamine neurons : nerve fiber outgrowth and L-DOPA effects

    Författare :Sara af Bjerkén; Ingrid Strömberg; Kathy Steece-Collier; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dopamine; nerve fiber outgrowth; astrocytes; ventral mesencephalon; GDNF; L-DOPA; L-DOPA induced dyskinesia; Neurobiology; Neurobiologi;

    Sammanfattning : Parkinson’s disease is a disorder mainly characterized by progressive degeneration of dopamine producing neurons in the substantia nigra of the midbrain. The most commonly used treatment strategy is to pharmacologically restore the lost function by the administration of the dopaminergic precursor L-DOPA. LÄS MER

  3. 2. The Role of Dopamine-Metabolising Enzymes in Renal Sodium Handling. An Experimental Study in vivo

    Författare :Cecilia Odlind; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology and anatomy; dopamine; kidney; sodium; MAO; COMT; rat; mice; RBF; oxygen; renal; L-dopa; DOPAC; entacapone; phenelzine; dopamine receptors; Fysiologi och anatomi; Physiology and pharmacology; Fysiologi och farmakologi; Physiology; fysiologi;

    Sammanfattning : Dopamine (DA) has been shown to act as an intrarenal natriuretic hormone and defects in the renal DA system have been associated with some forms of hypertension. How the DA activity is upregulated durin- increased sodium intake is, however, unknown. LÄS MER

  4. 3. Dopamine and the regulation of movements - significance of nigral and striatal dopamine release in normal, hemiparkinsonian and dyskinetic rats

    Författare :Daniel Andersson; Göteborgs universitet; []
    Nyckelord :dopamine; substantia nigra; striatum; L-DOPA; dyskinesias; serotonin;

    Sammanfattning : Introduction: The nigrostriatal dopamine (DA) containing neurones are a pivotal component in the basal ganglia, a network that regulates movement. Degeneration of these neurones causes the cardinal symptoms of Parkinson’s disease (PD). LÄS MER

  5. 4. PET applications in schizophrenia : Functional and pharmacological dopamine studies

    Författare :Ola Gefvert; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Schizophrenia; PET; dopamine synthesis rate; dopamine D2 receptor occupancy; atypical antipsychotics; quetiapine; risperidone microsphere depot; Neurovetenskap; Neurology; Neurologi; Psychiatry; psykiatri;

    Sammanfattning : Schizophrenia is a group of disorders with a worldwide lifetime prevalence of 0.85%. Thefunctional outcome of the disorder seem stable from the first systematic outcome studies to thepresent day, and vary only with changes in diagnostic criteria. LÄS MER

  7. 5. Cytochrome P450 2E1 - relevance for central dopamine neurotransmission and Parkinson's disease

    Författare :Haydeh Niazi Shahabi; Göteborgs universitet; []
    Nyckelord :cytochrome P450 2E1; dopamine; substantia nigra; polymorphism; alternative splicing;

    Sammanfattning : Introduction: The enzyme cytochrome P450 2E1 (CYP2E1) has been found in dopamine (DA) containing brain regions that are of relevance for Parkinson?s disease (PD), and is known to generate reactive oxygen species (ROS), toxic molecules that have been implicated in the degeneration of DA neurones. In addition, previous investigations have indicated that inhibition of CYP2E1 increases extracellular DA in the substantia nigra, a nucleus which degenerates in PD. LÄS MER