Sökning: "whole genome sequence"
Visar resultat 1 - 5 av 76 avhandlingar innehållade orden whole genome sequence.
1. Technologies for Single Cell Genome Analysis
Sammanfattning : During the last decade high throughput DNA sequencing of single cells has evolved from an idea to one of the most high profile fields of research. Much of this development has been possible due to the dramatic reduction in costs for massively parallel sequencing. LÄS MER
2. From Single Gene to Whole Genome Studies of Human Transcription Regulation
Sammanfattning : Transcriptional regulation largely determines which proteins and the protein levels that are found in a cell, and this is crucial in development, differentiation and responses to environmental stimuli. The major effectors of transcriptional regulation are a group of proteins known as transcription factors, which importance is supported by their frequent involvement in mendelian and complex diseases. LÄS MER
3. Methods for Analysis of Disease Associated Genomic Sequence Variation
Sammanfattning : In Molecular Medicine a wide range of methods are applied to analyze the genome to find genetic predictors of human disease. Apart from predisposing disease, genetic variations may also serve as genetic markers in the search for factors underlying complex diseases. LÄS MER
4. Rates and patterns of genome evolution in Lepidoptera
Sammanfattning : The evolutionary consequences of genome restructuring and chromosomal rearrangements can be significant, but the underlying mechanisms are poorly understood. This thesis explores the relationships between genome restructuring, recombination, and maintenance of genetic diversity in different butterfly species. LÄS MER
5. Exploring genetic diversity in natural and domestic populations through next generation sequencing
Sammanfattning : Studying genetic diversity in natural and domestic populations is of major importance in evolutionary biology. The recent advent of next generation sequencing (NGS) technologies has dramatically changed the scope of these studies, enabling researchers to study genetic diversity in a whole-genome context. LÄS MER