Sökning: "β-cell function"
Visar resultat 1 - 5 av 67 avhandlingar innehållade orden β-cell function.
1. Diabetes in Young Adults : Remission, β-cell function and markers of inflammation
Sammanfattning : Type 1 diabetes is caused by immuno-mediated β-cell destruction leading to insulin deficiency and hyperglycaemia. The decline in β-cell function and the clinical course after diagnosis vary. Whether the process of destruction of the β-cells is associated with markers of a non-specific inflammatory response is unknown. LÄS MER
2. Epac2 signaling at the β-cell plasma membrane
Sammanfattning : Secretion of appropriate amounts of insulin from pancreatic β-cells is crucial for glucose homeostasis. The β-cells release insulin in response to glucose and other nutrients, hormones and neurotransmitters, which trigger intracellular signaling cascades, that result in exocytotic fusion of insulin-containing vesicles with the plasma membrane. LÄS MER
3. Search for molecular and metabolic mechanisms contributing to impaired β-cell function
Sammanfattning : Type 2 Diabetes (T2D) prevalence is growing to pandemic proportions worldwide. The link between genotype, environment and β-cell function is still being investigated. LÄS MER
4. Neogenesis and alloxan toxicity in pancreatic islets, with special reference to the transplanted human β-cell
Sammanfattning : The aim of this work was to study whether adult human pancreatic β-cells have the capacity to proliferate in culture and after transplantation to the renal subcapsular space of mice. An immunosuppressive regimen for human islet discordant xenotransplantation to mice was designed. LÄS MER
5. Role of Inducible Nitric Oxide Synthase and Melatonin in Regulation of β-cell Sensitivity to Cytokines
Sammanfattning : The mechanisms of β-cell destruction leading to type 1 diabetes are complex and not yet fully understood, but infiltration of the islets of Langerhans by autoreactive immune cells is believed to be important. Activated macrophages and T-cells may then secrete cytokines and free radicals, which could selectively damage the β-cells. LÄS MER