Sökning: "5 P2"

Visar resultat 1 - 5 av 52 avhandlingar innehållade orden 5 P2.

  1. 1. Design and Synthesis of Malarial Aspartic Protease Inhibitors

    Författare :Karolina Ersmark; Anders Hallberg; Michael Rowley; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; malaria; plasmepsin; aspartic protease; protease inhibitor; macrocycle; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi;

    Sammanfattning : Malaria is one of the major public health problems in the world. Approximately 500 million people are afflicted and almost 3 million people die from the disease each year. Of the four causative species Plasmodium falciparum is the most lethal. LÄS MER

  2. 2. P2-purinergic receptors : new ligands, structure and signal transduction with emphasis on the guinea pig cochlea

    Författare :Leif Järlebark; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; Signalsubstanser; Hörselreceptorer;

    Sammanfattning : .... LÄS MER

  3. 3. Initiation of bacteriophage P2 rolling circle replication

    Författare :Richard Odegrip; Barbara Funnel; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; Virus; DNA; Genetics; genetik;

    Sammanfattning : Viruses are very simple entities. In its most simple form, the virus consists of a protein shell containing genetic material. To propagate the virus needs a host to parasitize, in which it can replicate its genetic material and assembly new virus particles. Viruses that parasitize bacteria are termed bacteriophages. LÄS MER

  4. 4. Novel functions of cardiovascular P2 receptors

    Författare :Anna-Karin Wihlborg; Kardiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cardiovascular system; Kardiovaskulära systemet; mRNA; EDHF; UTP; UDP; ADP; ATP; P2 receptor; contraction; dilatation; endothelial cells; Heart; VSMC;

    Sammanfattning : The aim of the thesis was to examine the expression and function of the extracellular nucleotide P2 receptors in the cardiovascular system. In the cardiovascular system nucleotides are released during shear stress, hypoxia, ischemia, from endothelial cells, smooth muscle cells, aggregating platelets, inflammatory cells and erythrocytes. LÄS MER

  5. 5. Expression and Regulation of P2 Receptors in Human Circulation

    Författare :Lingwei Wang; Sektion II; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Western blotting; Cardiovascular system; Kardiovaskulära systemet; vascular remodeling; systemic lupus erythematosus; smooth muscle cell; shear stress; real-time PCR; platelets; P2 receptor; gene expression; erythrocyte; ATP release; endothelium;

    Sammanfattning : P2 receptors mediate the actions of the extracellular nucleotides ATP, ADP, UTP and UDP regulating several physiological responses including cardiac function, vascular tone, smooth muscle cell (SMC) proliferation, platelet aggregation, and the release of endothelial factors. The aim of the present study was to investigate the mRNA and protein expression of P2 receptors in human SMCs, endothelial cells (ECs), erythrocytes and platelets, the regulation of P2 receptors under shear stress in human vessels, the changes of platelet P2 receptors in patients with systemic lupus erythematosus (SLE) and the regulation of plasma ATP levels by P2 receptor on erythrocytes. LÄS MER