Sökning: "pseudomonas exotoxin A"
Hittade 5 avhandlingar innehållade orden pseudomonas exotoxin A.
1. The Round Window Membrane - Gateway to the Cochlea : A Morphological and Electrophysiological study
Sammanfattning : Topical treatment of several inner ear diseases through the round window membrane (RWM) might be feasible in the near future. Bacteria toxins, ototoxic drugs and noise trauma seem to harm the inner ear by a common pathway which involves, excessive outflow of the afferent neurotransmitter glutamate and formation of nitric oxide (NO), which can severely damage cells/nerve endings and lead to cell death. LÄS MER
2. Tumor targeted delivery of cytotoxic payloads using affibody molecules and ABD-derived affinity proteins
Sammanfattning : Cancer treatment cost billions of dollars every year, but the mortality rate is still high. An ideal treatment is the so-called “magic bullets” that recognize and kill tumor cells while leaving normal cells untouched. LÄS MER
3. Time-related Aspects of Otoprotection : Experimental Studies in Rat
Sammanfattning : Intratympanic injection of various otoprotectants through the round window membrane (RWM) might become available in the near future as an alternative to the currently available medical and surgical methods used to treat several inner ear diseases. The most common outcome of such diseases is sensorineural hearing loss (SNHL). LÄS MER
4. Targeting HER2-expressing tumors with potent drug conjugates and fusion toxins based on scaffold proteins
Sammanfattning : Targeted therapy is an emerging treatment for a variety of cancers. Small- sized scaffold proteins are an alternative to conventional antibody-based targeting molecules. LÄS MER
5. Engineering of alternative scaffold derived drug conjugates and fusion-toxins for targeted cancer therapy
Sammanfattning : Cancer is a major health problem, with premature death for many patients, and with a high monetary cost to society. The disease is complex to treat due to the many different types, but also because the disease-causing cells, that needs to be removed, are very similar to the normal cells. LÄS MER