Sökning: "antilipolysis"
Hittade 5 avhandlingar innehållade ordet antilipolysis.
1. Adipocyte phosphatases and the antilipolytic action of insulin
Sammanfattning : Adipose tissue is the main site of energy storage of the body and an important endocrine organ. Knowledge of the regulation of fat metabolism and the endocrine factors secreted by the adipocyte is crucial for the understanding of diseases such as obesity and diabetes. Insulin is the main antilipolytic hormone. LÄS MER
2. Optimizing nicotinic acid delivery for durable antilipolysis and improved metabolic control
Sammanfattning : Type 2 diabetes is a devastating disease affecting hundreds of millions worldwide. Lipid accumulation in peripheral non-adipose tissues is a major driver of insulin resistance, a central pathophysiological defect of this disease. LÄS MER
3. Molecular Mechanism of Growth Hormone - Involvement of Janus Kinase 2, Insulin Receptor Substrate-1 and -2 and Phosphatidylinositol 3-Kinase In the Acute Insulin-Like Effects of Growth Hormone In Primary Rat Adipocytes
Sammanfattning : Originally studying the molecular mechanisms for the insulin-like effects of growth hormone (GH), lipogenesis and antilipolysis, in isolated rat adipocytes we found that the GH receptor (GHR) was tyrosine phosphorylated in response to GH in cells that were responsive to these effects. Then, as Janus kinase 2 (JAK2) was described as a GH-stimulated and GHR-associated tyrosine kinase, we found that JAK2 was tyrosine phosphorylated in response to GH in responsive cells. LÄS MER
4. Effects of surgery on substrate metabolism in human adipose tissue
Sammanfattning : The aim of this study was to characterize the effects of cholecystectomy on substrate metabolism in vivo and blood flow in adipose tissue using microdialysis of the tissue interstitial compartment. One day after surgery, general insulin resistance and glucose intolerance developed, there was no involvement of the glucose metabolism in adipose tissue. LÄS MER
5. Insulin Signalling and Regulation of Protein Kinase B in Adipocytes
Sammanfattning : Insulin resistance is a hallmark of type 2 diabetes, an increasingly common disorder. The cause of insulin resistance is supposedly failures in the processes used by insulin to signal to the interior of its target cells. These failing steps are still unknown, most probably because of incomplete knowledge of how the insulin signals are transmitted. LÄS MER