Sökning: "IL-18"

Visar resultat 1 - 5 av 63 avhandlingar innehållade ordet IL-18.

1. 1. Regulation of T cell effector functions in the intestinal mucosa

   Författare :Petra Holmkvist; Slemhinnans immunologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; T cells; memory; intestine; cytokines; differentiation; IL-18; inflammation; antigen presentation;

   Sammanfattning : T lymphocytes are a critical cellular component of the adaptive immune response. They are generated in the thymus from bone marrow derived progenitors, where they undergo commitment to the T cell lineage and differentiate and mature into naïve CD4+ and CD8+ T cells. LÄS MER

3. 2. Inflammatory response in the immature brainafter hypoxia-ischemia. Application of microarray and transgenic technology

   Författare :Maj Hedtjärn; Göteborgs universitet; []
   Nyckelord :hypoxia-ischemia; neonatal; brain; inflammation; cytokine; IL-1; IL-18; microglia; ; gene; microarray;

   Sammanfattning : Hypoxic-ischemic (HI) brain injury remains a common problem encountered during theneonatal period, and it is a major cause of perinatal mortality and long term neurologicalimpairments. After HI, an inflammatory reaction is elicited in the brain, which is believedto contribute to the secondary progression of brain injury. LÄS MER

4. 3. Innate and adaptive immunity in genital HSV-2 infection: Implications for vaccine development

   Författare :Ali M Harandi; Göteborgs universitet; []
   Nyckelord :genital herpes infection; natural antibody; CD4 T cells; CD8 T cells; IFN-g; IL-12; IL-18; CC chemokines; dendritic cells.;

   Sammanfattning : Herpes simplex virus type 2 (HSV-2) is a sexually transmitted pathogen that infects the genital tract mucosa and is the most common case of genital ulcers in humans. Despite numerous studies, little is known about the mechanisms involved in immune protection and no anti-herpes vaccine has been developed to date. LÄS MER

5. 4. Importance of bacterial hydrogen sulfide in the pathogenesis of periodontal diseases

   Författare :Amina Basic; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hydrogen sulfide; Periodontitis; Gingivitis; IL-1β; IL-18; NLRP3 inflammasome; Oral microbiota; Fusobacterium spp.; Bismuth test; L-cysteine;

   Sammanfattning : Hydrogen sulfide (H2S) is one of many end-products of the proteolytic activities in the subgingival microbiota in patients with periodontal diseases, such as gingivitis and periodontitis. Although H2S is generally regarded as toxic, the mechanisms that underlie its production and its effects on human cells and tissues are poorly understood. LÄS MER

7. 5. NO, Immunosuppression and Tumor Immmunotherapy

   Författare :Pontus Hegardt; Neurokirurgi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; serology; transplantation; Immunologi; serologi; IL-18; IFN-gamma; rat; colon carcinoma; glioma; tumor immunotherapy; immunosuppression; NO; iNOS;

   Sammanfattning : This study aims at clarifying the role of NO in the immunosuppression induced by in vivo tumor growth and by tumor immunotherapy, and determining whether the inhibition of NO production can be used as an adjuvant in tumor immunotherapy. We have shown previously that tumor cells, glioma (N32) and colon carcinoma (H1D2), when genetically engineered to express such immune stimulatory cytokines as IFN-g and IL-18, induce strong anti-tumor immune response, in immunized tumor-free rats, whereas only a limited therapeutic effect is achieved in rats in which a tumor has already become established. LÄS MER