Sökning: "electrokinetic chromatography"

Visar resultat 6 - 10 av 13 avhandlingar innehållade orden electrokinetic chromatography.

  1. 6. Sensitivity and selectivity studies in capillary electrophoresis

    Författare :Maria Petersson; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; peptides; dansyl amino acids; imaging detection; cyclodextrins; enantiomer separation; acoustic levitation; solid-phase extraction; preconcentration; capillary electrophoresis; micellar electrokinetic chromatography; drugs; Analytical chemistry; Analytisk kemi;

    Sammanfattning : Capillary electrophoresis is characterised by high separation efficiency, applicability to a wide range of compounds, small sample and solvent consumption and simple instrumentation. To improve sensitivity using on-line absorbance detectors, which are hampered by the short optical path length, sample volumes in the microlitre range were concentrated to nanolitre volumes either off-line or on-line. LÄS MER

  3. 7. Physicochemical and Biopharmaceutical Characterisation of Small Drug Molecules by Capillary Electrophoresis

    Författare :Eivor Örnskov; Staffan Folestad; Karin E. Markides; Morteza Khaledi; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Analytical chemistry; capillary electrophoresis CE ; micellar electrokinetic chromatography MEKC ; drug; liposome; microemulsion; coating; pKa; lipophilicity; multivariate analysis; molecular descriptor; hierarchical analysis; passiv absorption; Analytisk kemi; Analytical chemistry; Analytisk kemi;

    Sammanfattning : Capillary Electrophoresis (CE) was explored as a means for physicochemical and biopharmaceutical characterisation of small drug molecules. Special attention was paid to the characterisation of acid-base and lipophilic properties of drug compounds by analysing their migration behaviour in different CE systems. LÄS MER

  4. 8. Development of new methods for miniaturized separation techniques

    Författare :Marcus Öhman; Karlstads universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Kemi; Chemistry;

    Sammanfattning : The aim of this study has been to develop and investigate separation methods for miniaturized systems. Micro liquid chromatography was coupled on-line with a mass spectrometer equipped with an electrospray ionization source for the separation and characterization of flavonoids in Citrus juices. LÄS MER

  5. 9. Capillary electrophoresis methods for the separation of the basic compound lidocaine and its metabolites

    Författare :Magnus S. Andersson; Karlstads universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Kemi; Chemistry;

    Sammanfattning : For the separation of the basic compound lidocaine and its metabolites a variety of capillary electrophoresis (CE) methods have been developed. This includes capillary zone electrophoresis (CZE), micellar electrokinetic chromatography (MEKC) and nonaqueous CE separations. The parameters affecting the separations were investigated and optimized. LÄS MER

  7. 10. Determination of biomarkers for lipid peroxidation and oxidative stress : Development of analytical techniques and methods

    Författare :Kristina Claeson Bohnstedt; Bo Karlberg; Niels Heegaard; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; capillary electrophoresis; mass spectrometry; electrospray; porous graphitic carbon; oxidative stress; lipid peroxidation; biomarker; malondialdehyde; hydroxynonenal; isoprostane; Analytical chemistry; Analytisk kemi;

    Sammanfattning : Oxidative stress can be defined as a state of disturbance in the pro-oxidant/antioxidant balance in favour of the former, leading to potential damage. Processes associated with oxidative stress involve reactive oxygen species and radicals and can result in elevated levels of oxidatively modified or toxic molecules that can cause cellular malfunction, and even cell death. LÄS MER