Sökning: "hydroxynonenal"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet hydroxynonenal.

  1. 1. Determination of biomarkers for lipid peroxidation and oxidative stress : Development of analytical techniques and methods

    Författare :Kristina Claeson Bohnstedt; Bo Karlberg; Niels Heegaard; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; capillary electrophoresis; mass spectrometry; electrospray; porous graphitic carbon; oxidative stress; lipid peroxidation; biomarker; malondialdehyde; hydroxynonenal; isoprostane; Analytical chemistry; Analytisk kemi;

    Sammanfattning : Oxidative stress can be defined as a state of disturbance in the pro-oxidant/antioxidant balance in favour of the former, leading to potential damage. Processes associated with oxidative stress involve reactive oxygen species and radicals and can result in elevated levels of oxidatively modified or toxic molecules that can cause cellular malfunction, and even cell death. LÄS MER

  3. 2. Microsomal glutathione transferase 1 in anti-cancer drug resistance and protection against oxidative stress

    Författare :Katarina Johansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cancer is the second leading cause of death in privileged countries. Tremendous efforts have been done to improve the efficiency of cancer treatment. Anti-cancer drug resistance is still a major problem in failure of cancer therapy. LÄS MER

  4. 3. Demyelinating conditions regulated by ROS pathways outside and inside the brain

    Författare :Karl Carlström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Multiple sclerosis (MS) is a chronic inflammatory condition of the central nervous system with immune-mediated damage on myelinated nerve tracts. Accumulating evidence support a role for autoreactive T-lymphocytes orchestrating immuneattacks on myelinating oligodendrocytes (OLs). LÄS MER

  5. 4. Genetics in experimental traumatic brain injury

    Författare :Faiez Al Nimer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Traumatic brain injury (TBI) is the leading cause of death and disability in the young population in the industrialized world. It comprises a heterogeneous group of brain pathologies where head trauma initiates a series of complex molecular pathways, which, together with the initial injury, account for the final outcome. LÄS MER

  7. 5. Genetic variability commonly affecting neurodegeneration and neuroinflammation

    Författare :Mikael Ström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Loss of nerve cells and axons is a common feature of common complex neurodegenerative disorders, such as Alzheimer’s and Parkinson’s diseases. However, also Multiple Sclerosis (MS), primarily an autoimmune disorder, has a prominent neurodegenerative component. LÄS MER